Kashaninejad Navid, De Saram Prabuddha, Abdelfattah Mohamed A, Bakare Azeez, Vu Hoang Huy
Queensland Quantum and Advanced Technologies Research Institute, Griffith University, Nathan, QLD, Australia; School of Engineering and Built Environment, Griffith University, Australia.
Queensland Quantum and Advanced Technologies Research Institute, Griffith University, Nathan, QLD, Australia; School of Engineering and Built Environment, Griffith University, Australia.
Prog Mol Biol Transl Sci. 2025;215:311-354. doi: 10.1016/bs.pmbts.2025.05.005. Epub 2025 May 24.
Wearable biosensors have emerged as game changers in healthcare, particularly for cancer detection and monitoring. Continuously sensing physiological and biochemical markers improves cancer diagnosis and treatment significantly. Conventional diagnostic methods, such as biopsies and imaging, are invasive, expensive, and logistically challenging, limiting their frequency and accessibility. Over the past decade, advances in microfluidics and surface engineering have expanded the capabilities of wearable biosensors. Readily accessible body fluids, such as sweat, saliva, tears, and interstitial fluid (ISF), are now recognized as valuable, non-invasive sources of tumor biomarkers. These fluids provide critical insights into tumor progression and therapy response, offering a patient-friendly alternative to traditional diagnostics. The integration of cutting-edge materials, advanced sensing technologies, and microfluidics has dramatically enhanced the sensitivity and specificity of wearable biosensors. This progress paves the way for personalized and preventive healthcare, improving patient convenience and reducing clinical visits and invasive procedures. This chapter explores the fundamental design principles, practical applications, and existing challenges of wearable biosensors. By addressing these issues, wearable biosensors can play a transformative role in early cancer detection and personalized treatment, ultimately improving patient outcomes.
可穿戴生物传感器已成为医疗保健领域的变革者，尤其是在癌症检测和监测方面。持续感知生理和生化标志物可显著改善癌症的诊断和治疗。传统的诊断方法，如活检和成像，具有侵入性、成本高且在后勤方面具有挑战性，限制了其使用频率和可及性。在过去十年中，微流体技术和表面工程的进步扩展了可穿戴生物传感器的功能。易于获取的体液，如汗液、唾液、眼泪和间质液（ISF），现在被认为是肿瘤生物标志物的宝贵非侵入性来源。这些体液为肿瘤进展和治疗反应提供了关键见解，为传统诊断提供了一种患者友好的替代方案。前沿材料、先进传感技术和微流体技术的整合极大地提高了可穿戴生物传感器的灵敏度和特异性。这一进展为个性化和预防性医疗保健铺平了道路，提高了患者的便利性，减少了临床就诊和侵入性程序。本章探讨了可穿戴生物传感器的基本设计原则、实际应用和现有挑战。通过解决这些问题，可穿戴生物传感器可以在早期癌症检测和个性化治疗中发挥变革性作用，最终改善患者的治疗效果。
