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金纳米颗粒和γ-环糊精聚合物对一种源自二醛纤维素和樟脑噻唑-亚胺的新型席夫碱的物理化学、抗菌及抗生物膜性能的影响

Effect of gold nanoparticles and γ-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel schiff base derived from dialdehyde cellulose and camphor thiazole-imine.

作者信息

Mahdy Al-Hassan S, Hassan Entesar A, El-Sayyad Gharieb S, Taher Hadeer A, Zayed Salem E

机构信息

Department of Chemistry, Faculty of Science, South Valley University, Qena, 83523, Egypt.

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518059, China.

出版信息

BMC Microbiol. 2025 Jul 19;25(1):443. doi: 10.1186/s12866-025-03859-y.

DOI:10.1186/s12866-025-03859-y
PMID:40684085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12275303/
Abstract

The present study developed a novel antimicrobial composite based on 2,3-dialdehyde cellulose (DAC), with biocompatible properties and long-term stability. Initially, DAC was synthesized through the periodate oxidation of microcrystalline cellulose, achieving a 61% degree of oxidation. Subsequently, the DAC was successfully modified through the formation of a Schiff base with CTI in the basic medium. The antimicrobial efficacy of the synthesized DAC-CTI was strengthened by the synthesis of Au NPs via a green chemical approach using lemon extract and their subsequent grafting into the DAC-CTI matrix, followed by encapsulation of the produced DAC-CTI/Au nanocomposite into the γ-cyclodextrin ring. The TEM results of DAC-CTI/Au nanocomposite indicated an average Au particle size of 37.4 nm within the nanocomposite. The evaluated samples reveal a positive efficacy against a variety of bacteria, including P. aeruginosa, C. albicans, and S. aureus. Particularly, DAC-CTI/Au NPs/γ-CD exhibited the highest effect on S. aureus (19.0 mm zone of inhibition (ZOI) and 2.5 µg/mL MIC), E. coli (20.0 mm ZOI and 1.25 µg/mL MIC), and C. albicans (18.2 mm ZOI and 2.5 µg/mL MIC). The outcomes achieved open the door to the practical implementation of intriguing compounds in biological fields.

摘要

本研究基于2,3-二醛基纤维素（DAC）开发了一种新型抗菌复合材料，具有生物相容性和长期稳定性。最初，通过微晶纤维素的高碘酸盐氧化合成DAC，氧化度达到61%。随后，在碱性介质中通过与CTI形成席夫碱成功修饰DAC。通过使用柠檬提取物的绿色化学方法合成金纳米颗粒（Au NPs），并将其随后接枝到DAC-CTI基质中，然后将生成的DAC-CTI/Au纳米复合材料封装到γ-环糊精环中，增强了合成的DAC-CTI的抗菌效果。DAC-CTI/Au纳米复合材料的透射电镜（TEM）结果表明，纳米复合材料中Au颗粒的平均粒径为37.4nm。评估的样品对多种细菌显示出积极的抗菌效果，包括铜绿假单胞菌、白色念珠菌和金黄色葡萄球菌。特别是，DAC-CTI/Au NPs/γ-CD对金黄色葡萄球菌（抑菌圈（ZOI）为19.0mm，最低抑菌浓度（MIC）为2.5μg/mL）、大肠杆菌（ZOI为20.0mm，MIC为1.25μg/mL）和白色念珠菌（ZOI为18.2mm，MIC为2.5μg/mL）表现出最高的抗菌效果。所取得的成果为在生物领域实际应用这些有趣的化合物打开了大门。

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本文引用的文献

1
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Molecules. 2023 Jul 27;28(15):5694. doi: 10.3390/molecules28155694.
2
Dialdehyde Cellulose Solution as Reducing Agent: Preparation of Uniform Silver Nanoparticles and In Situ Synthesis of Antibacterial Composite Films with High Barrier Properties.二醛纤维素溶液作为还原剂：制备均匀的银纳米粒子和原位合成具有高阻隔性能的抗菌复合薄膜。
Molecules. 2023 Mar 26;28(7):2956. doi: 10.3390/molecules28072956.
3
Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
纳米二氧化钛和β-环糊精聚合物对新型壳聚糖-樟脑聚合物的物理化学、抗菌和抗生物膜性能的影响。
Int J Biol Macromol. 2022 Oct 31;219:1062-1079. doi: 10.1016/j.ijbiomac.2022.07.249. Epub 2022 Aug 6.
4
Compositional Analysis of Four Kinds of Citrus Fruits with an NMR-Based Method for Understanding Nutritional Value and Rational Utilization: From Pericarp to Juice.基于 NMR 的方法分析四种柑橘类水果的成分，了解其营养价值和合理利用：从果皮到果汁。
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5
An Efficient Protocol for the Synthesis of new Camphor Pyrimidine and Camphor Thiazole Derivatives using Conventional and Microwave Irradiation Techniques and Evaluation as Potential Antimicrobial Agents.一种使用常规和微波辐射技术合成新型樟脑嘧啶和樟脑噻唑衍生物的高效方案及其作为潜在抗菌剂的评估。
Curr Org Synth. 2022;19(4):558-568. doi: 10.2174/1570179419666220104125340.
6
A fast method to measure the degree of oxidation of dialdehyde celluloses using multivariate calibration and infrared spectroscopy.使用多元校正和红外光谱法快速测定二醛纤维素的氧化程度。
Carbohydr Polym. 2022 Feb 15;278:118887. doi: 10.1016/j.carbpol.2021.118887. Epub 2021 Nov 26.
7
A new approach for antimicrobial and antiviral activities of biocompatible nanocomposite based on cellulose, amino acid and graphene oxide.基于纤维素、氨基酸和氧化石墨烯的生物相容性纳米复合材料的抗菌和抗病毒活性的新方法。
Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 1):112172. doi: 10.1016/j.colsurfb.2021.112172. Epub 2021 Oct 20.
8
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9
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Carbohydr Polym. 2021 May 1;259:117740. doi: 10.1016/j.carbpol.2021.117740. Epub 2021 Feb 6.
10
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Int J Biol Macromol. 2021 Apr 15;176:530-539. doi: 10.1016/j.ijbiomac.2021.02.099. Epub 2021 Feb 16.