Gáspár Zsófia, Tresó Bálint, Kocsis Laura, Lakatos Botond
1 Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet, Infektológiai Osztály Budapest, Albert Flórián út 5-7., 1097 Magyarország.
2 Semmelweis Egyetem, Doktori Iskola, Rácz Károly Konzervatív Orvostudományi Tagozat Budapest Magyarország.
Orv Hetil. 2025 Jul 20;166(29):1132-1138. doi: 10.1556/650.2025.33334.
Introduction: Human metapneumovirus (hMPV) is a respiratory pathogen that can cause severe complications, particularly in patients with certain comorbidities. Its significance has grown due to insights from the COVID–19 pandemic and the rising hMPV cases reported by the Chinese Centre for Disease Control and Prevention in late 2024. Objective: The aim of the study was to retrospectively analyze the epidemiological and clinical characteristics of hMPV cases diagnosed between 2019 and 2024 at the Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases. Method: A single-center, retrospective cohort study was conducted between December 2019 and December 2024, including all adult patients who had confirmed hMPV infection by real-time polymerase chain reaction (RT-PCR). Clinical data (demographics, comorbidities, initial clinical presentation, viral co-infection) and complications (hospitalization, oxygen requirement, pneumonitis, intensive care unit admission, mechanical ventilation, in-hospital mortality) were recorded. The primary composite endpoint, which also determined the complicated course, was based on in-hospital mortality, intensive care unit admission, or mechanical ventilation initiation. Results: A total of 80 patients were included (mean age: 58 ± 30 years; male: n = 47, 58.8%). A complicated course was observed in 10% (n = 8), which occurred significantly more frequently in older patients (66 ± 10 vs. 55±31 years, p = 0.05). Pneumonitis occurred in 45% (n = 36), hospitalization in 42.5% (n = 34), oxygen requirement in 30% (n = 24), intensive care unit admission in 8.75% (n =7), mechanical ventilation in 6.25% (n = 5), and in-hospital mortality in 6.25% (n = 5). Intensive care unit admission and in-hospital mortality were not always exclusively due to hMPV infection. Discussion: According to our findings, the clinical significance of hMPV is important in immunocompromised, elderly, and patients with chronic respiratory diseases, as the infection can lead to severe respiratory complications. Conclusion: In summary, when hMPV infection is suspected, diagnostics should be extended including hMPV, particularly in high-risk groups, as early diagnosis is crucial for preventing severe outcomes. Orv Hetil. 2025; 166(29): 1132–1138.
人偏肺病毒（hMPV）是一种呼吸道病原体，可导致严重并发症，尤其是在患有某些合并症的患者中。由于新冠疫情带来的深刻认识以及中国疾病预防控制中心在2024年末报告的hMPV病例增加，其重要性日益凸显。目的：本研究旨在回顾性分析2019年至2024年期间在南方害虫国家血液学和传染病研究所中央医院确诊的hMPV病例的流行病学和临床特征。方法：在2019年12月至2024年12月期间进行了一项单中心回顾性队列研究，纳入所有通过实时聚合酶链反应（RT-PCR）确诊hMPV感染的成年患者。记录临床数据（人口统计学、合并症、初始临床表现、病毒合并感染）和并发症（住院、吸氧需求、肺炎、重症监护病房收治、机械通气、院内死亡）。主要复合终点（也用于确定复杂病程）基于院内死亡、重症监护病房收治或开始机械通气。结果：共纳入80例患者（平均年龄：58±30岁；男性：n = 47，58.8%）。观察到10%（n = 8）的患者病程复杂，在老年患者中发生频率显著更高（66±10岁 vs. 55±31岁，p = 0.05）。肺炎发生率为45%（n = 36），住院率为42.5%（n = 34），吸氧需求率为30%（n = 24），重症监护病房收治率为8.75%（n = 7），机械通气率为6.25%（n = 5），院内死亡率为6.25%（n = 5）。重症监护病房收治和院内死亡并不总是完全由hMPV感染所致。讨论：根据我们的研究结果，hMPV的临床意义在免疫功能低下、老年和慢性呼吸系统疾病患者中很重要，因为感染可导致严重的呼吸道并发症。结论：总之，当怀疑hMPV感染时，诊断应扩展至包括hMPV检测，尤其是在高危人群中，因为早期诊断对于预防严重后果至关重要。《匈牙利医学周报》。2025年；166(29): 1132–1138。
