Wang Jia-Wei, Su Jing, Ma Fei-Yan, Wang Jin, Liu Ying, Shi Jin-Xin, Ma Jing-Xue, Liu Dan-Yan
Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Int J Ophthalmol. 2025 Jul 18;18(7):1333-1340. doi: 10.18240/ijo.2025.07.17. eCollection 2025.
To elucidate the manifestations and associated complications observed in patients with intraocular silicone oil (SO) emulsification through multiple imaging modalities.
This single-center, observational, retrospective study included 116 patients who underwent pars plana vitrectomy (PPV) with SO injection for retinal detachment (RD), followed by subsequent SO removal at the Second Hospital of Hebei Medical University from January 2013 to January 2023. Comprehensive records of ophthalmic examinations utilizing multiple imaging techniques were maintained.
The study comprised 56 females and 60 males, with a mean age of 52.75±13.6y. The mean follow-up duration for SO tamponade was 9.04±11.33mo (range: 1-84mo). Among the participants, 59 patients were diagnosed with SO emulsification, while 57 patients were in the SO unemulsified group. Patients with SO emulsification had a significantly prolonged SO tamponade duration (<0.01). Multiple imaging techniques revealed notable signs of SO emulsification and its complications, such as 4 cases (3.4%) with posterior corneal SO-like keratic precipitates (KP) observed by anterior segment photography, 23 cases (19.8%) exhibiting spherical high-reflection signals in the inter-retina, retinal pigment epithelium, or choroid detected by Spectralis spectral domain optical coherence tomography (SD-OCT), 4 cases (3.4%) showing slow movement of emulsified SO droplets within retinal vessels during fluorescein angiography (FFA), plain and enhanced head magnetic resonance imaging (MRI) images of these four patients did not detect emulsified SO in the lateral ventricles, suprasellar cistern, subarachnoid space, third ventricle, fourth ventricle, or other intracranial locations.
Intraocular emulsified SO can lead to damage in both anterior and posterior segment tissues, encompassing corneal degeneration, cataracts, glaucoma, retinal and choroid inflammation. Objective multiple imaging techniques such as anterior segment photography, SD-OCT, FFA, and MRI offer comprehensive evaluation and diagnosis of SO emulsification and its associated complications.
通过多种成像方式阐明眼内硅油（SO）乳化患者的表现及相关并发症。
本单中心、观察性、回顾性研究纳入了116例因视网膜脱离（RD）接受玻璃体切除联合SO注入术，随后于2013年1月至2023年1月在河北医科大学第二医院进行SO取出术的患者。保存了利用多种成像技术进行眼科检查的综合记录。
该研究包括56名女性和60名男性，平均年龄为52.75±13.6岁。SO填塞的平均随访时间为9.04±11.33个月（范围：1 - 84个月）。参与者中，59例被诊断为SO乳化，57例为未乳化SO组。SO乳化患者的SO填塞时间显著延长（<0.01）。多种成像技术揭示了SO乳化及其并发症的显著迹象，如眼前段照相观察到4例（3.4%）角膜后有SO样角膜后沉着物（KP），光谱域光学相干断层扫描（SD - OCT）检测到23例（19.8%）在视网膜、视网膜色素上皮或脉络膜间呈现球形高反射信号，荧光素血管造影（FFA）期间4例（3.4%）显示乳化的SO液滴在视网膜血管内缓慢移动，这4例患者的头颅平扫和增强磁共振成像（MRI）图像未在侧脑室、鞍上池、蛛网膜下腔、第三脑室、第四脑室或其他颅内部位检测到乳化的SO。
眼内乳化SO可导致眼前段和眼后段组织损伤，包括角膜变性、白内障、青光眼、视网膜和脉络膜炎症。眼前段照相、SD - OCT、FFA和MRI等客观的多种成像技术为SO乳化及其相关并发症提供了全面的评估和诊断。
