Qureshi A A, Burger W C, Peterson D M, Elson C
Lipids. 1985 Nov;20(11):817-24. doi: 10.1007/BF02534407.
In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio-protective component of the vegetarian diet consists of a variety of non-sterol, post-mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol-suppressive action of plant materials is expressed.
在动物体内，甲羟戊酸途径的非甾醇代谢产物在甲羟戊酸生物合成的多价反馈调节中独立于受体介导的胆固醇摄取起作用。本文综述了导致植物源性甲羟戊酸生物合成抑制剂分离和表征的研究。我们提出，素食饮食的一种心脏保护成分包括多种非甾醇的甲羟戊酸后代谢产物。随着动物的进化而被舍弃的甲羟戊酸途径植物分支的这些产物，继续影响动物甾醇代谢。我们认为，正是通过这种作用，植物材料的胆固醇抑制作用得以体现。
