Hsu Chou-Yi, Jasim Saade Abdalkareem, Jyothi Renuka S, Ahmad Irfan, Hjazi Ahmed, Alubiady Mahmood Hasen Shuhata, Sinha Aashna, Mustafa Yasser Fakri, Al-Ani Ahmed Muzahem, Hussn Ahmed
Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, AZ, 85004, USA.
Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 21. doi: 10.1007/s00210-025-04407-1.
A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.
当成熟的转运RNA（tRNA）或tRNA前体被切割时，会产生一类新的微小非编码RNA（ncRNA），称为tRNA衍生片段（tRF）。高通量测序技术的进步使得人们发现了越来越多在许多生理和病理过程中发挥重要作用的tRF。tRF被认为是人类疾病，尤其是癌症的重要调节因子，因为它们可能通过多种方式控制细胞活力、分化和内环境稳定。此外，越来越多的证据表明，细胞外tRF可作为癌症液体活检诊断和预后的潜在生物标志物。tRF的生物发生、分类和改变是本综述的主要主题。我们还概述了tRF在乳腺癌（BC）中的各种作用，重点介绍了该领域tRF的研究现状和未来方向。
