Moss D, Ma A, Cameron D P
Metabolism. 1985 Dec;34(12):1094-9. doi: 10.1016/0026-0495(85)90152-0.
We studied diet-induced thermogenesis (DIT) in cafeteria fed monosodium glutamate (MSG) and saline-treated mice. From 12 weeks of age MSG and saline-treated mice were fed a diet of either standard chow or a cafeteria diet of standard chow supplemented with chocolate or biscuits on alternate days for six weeks. There was a significant weight gain in cafeteria fed MSG-treated mice but not in cafeteria fed saline-treated mice. In cafeteria fed MSG-treated mice there was a significant increase in resting oxygen consumption. The response to exogenous norepinephrine was significantly increased in cafeteria fed saline-treated mice. The level of specific tritiated guanosine 5'-diphosphate binding to isolated mitochondrial fractions was significantly increased in both cafeteria fed MSG and saline-treated mice. It is concluded that (1) cafeteria feeding is capable of promoting DIT, within brown adipose tissue (BAT), in MSG-treated mice and (2) the mechanisms for the induction of thermoregulatory thermogenesis (TRT) and DIT are distinct since cold-induced TRT has previously been shown to be defective in MSG-treated mice.
我们研究了在喂食自助餐厅式饮食的味精（MSG）处理小鼠和生理盐水处理小鼠中的饮食诱导产热（DIT）。从12周龄起，MSG处理小鼠和生理盐水处理小鼠交替喂食标准饲料或添加巧克力或饼干的标准饲料组成的自助餐厅式饮食，持续六周。喂食自助餐厅式饮食的MSG处理小鼠体重显著增加，而喂食自助餐厅式饮食的生理盐水处理小鼠体重未增加。喂食自助餐厅式饮食的MSG处理小鼠静息氧消耗显著增加。喂食自助餐厅式饮食的生理盐水处理小鼠对外源性去甲肾上腺素的反应显著增强。在喂食自助餐厅式饮食的MSG处理小鼠和生理盐水处理小鼠中，与分离的线粒体组分结合的特定氚标记鸟苷5'-二磷酸水平均显著增加。得出的结论是：（1）在MSG处理的小鼠中，自助餐厅式饮食能够促进棕色脂肪组织（BAT）内的DIT；（2）体温调节性产热（TRT）和DIT的诱导机制是不同的，因为先前已表明冷诱导的TRT在MSG处理的小鼠中存在缺陷。
