Puspitasari Maya Khaerunnisa, Siddiq Amillia, Virgana Rova, Pramatirta Akhmad Yogi, Irianti Setyorini, Handono Budi, Mose Johanes Cornelius, Effendi Jusuf Sulaeman
Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Bandung General Hospital, Bandung, West Java, Indonesia.
Department of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran - Cicendo Hospital, Bandung, West Java, Indonesia.
Med Sci Monit. 2025 Jul 22;31:e947528. doi: 10.12659/MSM.947528.
BACKGROUND Doppler ultrasonography has emerged as a non-invasive method for evaluating vascular changes in preeclampsia. The ophthalmic artery emerges a novel target for hemodynamic assessment in preeclampsia. This study aimed to compare the Doppler ultrasound pulsatility index (PI) and resistive index (RI). PI and RI in the ophthalmic artery and uterine artery were measured in 60 pregnant women with and without preeclampsia. MATERIAL AND METHODS A cross-sectional design study was conducted to measure Doppler parameters of the uterine and the ophthalmic artery involving 30 participants in preeclampsia and 30 participants in non-preeclampsia groups in West Java from July to September 2024. Doppler ultrasound was performed (Voluson GE S8 BT-equipped with a 7.5 MHz linear transducer, operated by a single maternal-fetal medicine trainee) to measure PI and RI values in the uterine (normal 0.45-0.5) and ophthalmic arteries (normal 0.6-0.7). Bivariate statistical analysis and Pearson correlation tests were performed as further analysis. RESULTS The study found that the uterine artery's PI and RI were significantly higher in the preeclampsia group than in the normal group (P<0.0001). In contrast, the ophthalmic artery's PI and RI were significantly lower in the preeclampsia group (P<0.0001). There was a negative correlation between the RI of the uterine artery and ophthalmic artery, with a coefficient value of -0.19 and statistically significance (P=0.01) in the preeclampsia group. CONCLUSIONS The findings suggest PI and RI changes and a significant correlation between uterine and ophthalmic artery RI values, reflecting systemic endothelial dysfunction in preeclampsia.
背景 多普勒超声已成为评估子痫前期血管变化的一种非侵入性方法。眼动脉成为子痫前期血流动力学评估的一个新靶点。本研究旨在比较多普勒超声搏动指数（PI）和阻力指数（RI）。对60例患有和未患子痫前期的孕妇测量其眼动脉和子宫动脉的PI和RI。
材料与方法 进行了一项横断面设计研究，以测量子宫和眼动脉的多普勒参数，研究对象包括2024年7月至9月在西爪哇的30例子痫前期参与者和30例非子痫前期组参与者。采用多普勒超声（配备7.5 MHz线性探头的GE Voluson S8 BT，由一名母胎医学实习生操作）测量子宫（正常0.45 - 0.5）和眼动脉（正常0.6 - 0.7）的PI和RI值。进一步分析采用双变量统计分析和Pearson相关性检验。
结果 研究发现，子痫前期组子宫动脉的PI和RI显著高于正常组（P<0.0001）。相比之下，子痫前期组眼动脉的PI和RI显著更低（P<0.0001）。子痫前期组子宫动脉和眼动脉的RI之间存在负相关，系数值为 -0.19，具有统计学意义（P = 0.01）。
结论 研究结果表明PI和RI发生变化，且子宫和眼动脉RI值之间存在显著相关性，反映了子痫前期的全身内皮功能障碍。
