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[人血浆中的维生素D结合蛋白。遗传变异分析]

[Vitamin D-binding protein in human plasma. Analysis of genetic variation].

作者信息

Cleve H

出版信息

Naturwissenschaften. 1985 Oct;72(10):519-26. doi: 10.1007/BF00367597.

DOI:10.1007/BF00367597
PMID:4069226
Abstract

The vitamin-D-binding protein (DBP) also known as group-specific component (GC) is described. This transport protein for vitamin D and its metabolic derivatives has genetic variants which are disclosed by electrophoretic procedures or by isoelectric focusing. Three common and one hundred rare alleles are known. The biochemical, molecular and population genetics are briefly outlined as an example of inherited variability in man.

摘要

本文描述了维生素D结合蛋白（DBP），也称为组特异性成分（GC）。这种维生素D及其代谢衍生物的转运蛋白具有遗传变异，可通过电泳程序或等电聚焦来揭示。已知有三种常见等位基因和一百种罕见等位基因。作为人类遗传变异性的一个例子，简要概述了其生化、分子和群体遗传学。

相似文献

1
[Vitamin D-binding protein in human plasma. Analysis of genetic variation].[人血浆中的维生素D结合蛋白。遗传变异分析]
Naturwissenschaften. 1985 Oct;72(10):519-26. doi: 10.1007/BF00367597.
2
Genetic polymorphism of the vitamin D-binding protein (DBP) in crab-eating macaques (Macaca fascicularis).食蟹猕猴（Macaca fascicularis）中维生素D结合蛋白（DBP）的基因多态性。
J Med Primatol. 1991 May;20(3):126-32.
3
The group specific component/vitamin D binding protein (GC/DBP) system in the analysis of disputed paternities.
Electrophoresis. 1988 Aug;9(8):398-403. doi: 10.1002/elps.1150090809.
4
Interaction of the vitamin D-binding protein (group-specific component) and its ligand 25-hydroxy-vitamin D3: binding differences of the various genetic types disclosed by isoelectric focusing.维生素D结合蛋白（群体特异性成分）与其配体25-羟基维生素D3的相互作用：等电聚焦揭示的各种基因类型的结合差异
Electrophoresis. 1990 Jun;11(6):478-83. doi: 10.1002/elps.1150110608.
5
Identification of group specific component/vitamin D-binding protein (GC/DBP) mutants by isoelectric focusing in immobilized pH gradients.通过在固定化pH梯度中进行等电聚焦鉴定群体特异性成分/维生素D结合蛋白（GC/DBP）突变体。
Electrophoresis. 1988 Sep;9(9):599-602. doi: 10.1002/elps.1150090922.
6
Polymorphism of the vitamin D binding protein (DBP) among primates: an evolutionary analysis.灵长类动物中维生素D结合蛋白（DBP）的多态性：进化分析
Am J Phys Anthropol. 1987 Jul;73(3):365-77. doi: 10.1002/ajpa.1330730307.
7
A comparative study of immuno-blotting techniques for the detection of Gc-subtypes after isoelectric focusing on agarose and polyacrylamide gels.琼脂糖和聚丙烯酰胺凝胶等电聚焦后检测Gc亚型的免疫印迹技术的比较研究。
Z Rechtsmed. 1987;98(3):175-80. doi: 10.1007/BF00200340.
8
A rare GC mutant in horses disclosed by isoelectric focusing and subsequent immunoprinting.
Exp Clin Immunogenet. 1991;8(1):49-54.
9
Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP).与人类血清载体蛋白（DBP）基因亚型相关的维生素D代谢物的亲和力差异。
Hum Genet. 1993 Sep;92(2):183-8. doi: 10.1007/BF00219689.
10
Gc subtypes identified by isoelectric focusing in baboons (Papio hamadryas).通过等电聚焦在狒狒（阿拉伯狒狒）中鉴定出的Gc亚型。
Hum Genet. 1985;69(1):89-90. doi: 10.1007/BF00295537.

引用本文的文献

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High PD-L1 expression is associated with therapeutic response to pembrolizumab in patients with advanced biliary tract cancer.高 PD-L1 表达与晚期胆道癌患者接受 pembrolizumab 治疗的反应相关。
Sci Rep. 2020 Jul 23;10(1):12348. doi: 10.1038/s41598-020-69366-4.
2
AIDS: no association with the genetic systems GC (D-binding protein), ORM (orosomucoid = alpha-1-acid glycoprotein), and A2HS (alpha-2-HS-glycoprotein).艾滋病：与遗传系统GC（D结合蛋白）、ORM（血清类粘蛋白=α-1-酸性糖蛋白）和A2HS（α-2-HS-糖蛋白）无关联。
Infection. 1988;16(1):31-5. doi: 10.1007/BF01646929.

本文引用的文献

1
Immune-electrophoretic demonstration of qualitative differences in human sera and their relation to the haptoglobins.人血清中定性差异的免疫电泳显示及其与触珠蛋白的关系。
Acta Pathol Microbiol Scand. 1959;47:160-8. doi: 10.1111/j.1699-0463.1959.tb04844.x.
2
THE DISTRIBUTION OF GC-TYPES IN SERA FROM AUSTRALIAN ABORIGINES.澳大利亚原住民血清中GC类型的分布。
Am J Phys Anthropol. 1963 Jun;21(2):215-23. doi: 10.1002/ajpa.1330210213.
3
TWO GENETIC VARIANTS OF THE GROUP-SPECIFIC COMPONENT OF HUMAN SERUM: GC CHIPPEWA AND GC ABORIGINE.
人血清群体特异性成分的两种基因变体：GC奇珀瓦型和GC原住民型。
Am J Hum Genet. 1963 Dec;15(4):368-79.
4
ISOLATION AND PARTIAL CHARACTERIZATION OF THE TWO PRINCIPAL INHERITED GROUP-SPECIFIC COMPONENTS OF HUMAN SERUM.人血清中两种主要遗传性群体特异性成分的分离与部分特性鉴定
J Exp Med. 1963 Nov 1;118(5):711-26. doi: 10.1084/jem.118.5.711.
5
Studies on the "group specific component" of human serum. Gene frequencies in several populations.人类血清“群体特异性成分”的研究。若干人群中的基因频率。
Am J Hum Genet. 1961 Dec;13(4):372-8.
6
Studies of antiricketic activity in sera from patients with disorders of calcium metabolism and preliminary observations on the mode of transport of vitamin D in human serum.钙代谢紊乱患者血清中抗佝偻病活性的研究以及维生素D在人血清中转运方式的初步观察。
J Clin Invest. 1959 Jul;38(7):1078-85. doi: 10.1172/JCI103884.
7
[Method permitting the combined study of the electrophoretic and the immunochemical properties of protein mixtures; application to blood serum].[蛋白质混合物电泳和免疫化学性质联合研究方法；应用于血清]
Biochim Biophys Acta. 1953 Jan;10(1):193-4. doi: 10.1016/0006-3002(53)90233-9.
8
The distribution of Gc subtypes among the mongoloid populations.蒙古人种群体中Gc亚型的分布。
Am J Phys Anthropol. 1980 Nov;53(4):505-8. doi: 10.1002/ajpa.1330530406.
9
Binding of the apo and holo forms of the serum vitamin D-binding protein to human lymphocyte cytoplasm and membrane by indirect immunofluorescence.通过间接免疫荧光法检测血清维生素D结合蛋白的脱辅基形式和全蛋白形式与人类淋巴细胞细胞质及细胞膜的结合情况。
Immunol Lett. 1981 Aug;3(3):159-62. doi: 10.1016/0165-2478(81)90120-6.
10
Gc, Tf, Hp subtype and alpha 1-antitrypsin polymorphisms in a Pygmy Bi-Aka sample.
Hum Hered. 1981;31(3):129-37. doi: 10.1159/000153195.