Yang Barbara, Sedano Melina J, Diwa Kimberly, Dominguez Johnathan, Boisselier Gabriela, Harrison Alana L, Reid Victoria A, Ramos Enrique I, Jimenez Maria V, Sanchez-Michael Laura A, Kolli Shreya, Patel Jai, Lee Debra, Vijayaraghavan Mahalakshmi, Chacon Jessica, Dhandayuthapani Subramanian, Gadad Shrikanth S
Center of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, United States.
South Texas Center of Excellence in Cancer Research, Department of Medicine and Oncology, The University of Texas Rio Grande Valley School of Medicine, McAllen, Texas-78504, United States.
Clin Transl Discov. 2025 Jun;5(3). doi: 10.1002/ctd2.70055. Epub 2025 May 25.
Recent high-throughput sequencing technologies have discovered various polymerase II transcribed transcripts. The majority of them are non-protein-coding, understudied, and poorly conserved. Noncoding transcripts are categorized based on their location in the genome and the direction in which they are transcribed; these categories classify a noncoding transcript as either antisense, intergenic, or divergent. The RNAs belonging to divergent classes consist of two transcripts, transcribed in sense and antisense direction, generated from the same promoter or locus. Multiple environmental and genetic cues can determine the regulation of these transcripts. One of the well-known signaling molecules, estrogen, has been shown to play a vital role in the activation and regulation of divergent transcripts by mediating effects through the estrogen receptors. Emerging studies have shown a strong causative effect between estrogen-regulated divergent transcripts and diseases such as cancer. However, few, viz., , , and , show a causal relationship with estrogen-dependent biology. This mini-review summarizes their role in estrogen-dependent processes that may drive the research to identify novel estrogen-signaling regulators.
近期的高通量测序技术发现了各种聚合酶II转录的转录本。其中大多数是非蛋白质编码的，研究不足且保守性较差。非编码转录本根据其在基因组中的位置和转录方向进行分类；这些类别将非编码转录本分为反义、基因间或发散型。属于发散类别的RNA由两个转录本组成，它们从同一启动子或基因座以正义和反义方向转录。多种环境和遗传线索可以决定这些转录本的调控。一种著名的信号分子雌激素已被证明通过雌激素受体介导作用，在发散转录本的激活和调控中发挥重要作用。新兴研究表明，雌激素调节的发散转录本与癌症等疾病之间存在强烈的因果关系。然而，很少有研究（即 、 、 和 ）显示与雌激素依赖性生物学存在因果关系。本综述总结了它们在雌激素依赖性过程中的作用，这可能推动研究去识别新的雌激素信号调节剂。
