Okudzhava V M, Goff V G, Zolotilina E G
Neirofiziologiia. 1985;17(5):601-6.
The possibility of cortical "kindling" organization in short time interval (2-3 hours) was shown in acute experiment on cats. The middle area of g. suprasilvius was stimulated by square current pulses (20 per s, 1 ms duration for 5 s with interstimulus intervals of 3 min). As a result of stimulation after the projection discharge in the mirror focus the convulsive activity generalization and formation of independent secondary focuses were observed. In the process of formation of cortical "kindling" the activity of spindle waves could be recorded in all ECoG traces. The frequency of spindle emergence grew according to the epileptization of the animal. The spindle activity transformation into the multiple spike-wave activity was also recorded. The results obtained proved the participation of subcortical structures in the formation of cortical "kindling".
在对猫进行的急性实验中，已证实在短时间间隔（2 - 3小时）内存在皮质“点燃”组织的可能性。通过方形电流脉冲（每秒20次，持续时间1毫秒，持续5秒，刺激间隔为3分钟）刺激上薛氏回的中间区域。在镜像焦点的投射放电后进行刺激，结果观察到惊厥活动的泛化以及独立继发性焦点的形成。在皮质“点燃”形成过程中，在所有脑电图记录中均可记录到纺锤波活动。纺锤波出现的频率随动物癫痫化程度增加。还记录到纺锤波活动转变为多棘波活动。所获结果证明皮质下结构参与了皮质“点燃”的形成。
