Analysis of gene polymorphisms in patients with pulmonary infections based on next-generation sequencing technology and their prognostic predictive value.

Pulmonary infections are a leading cause of morbidity and mortality worldwide, particularly among vulnerable populations such as children and the older adult. Gene polymorphisms play a critical role in disease susceptibility, progression, and prognosis, yet their specific contributions to pulmonary infections remain underexplored. This study utilized next-generation sequencing (NGS) technology to analyze gene polymorphisms in 200 patients with pulmonary infections and evaluate their prognostic value. Key findings include significant associations between polymorphisms in TLR4 (rs4986790), IL-10 (rs1800896), TNF-α (rs1800629), and MBL2 (rs1800450) with infection susceptibility, disease severity, and survival outcomes. Notably, carriers of the TLR4 rs4986790 mutation exhibited increased risk of severe infections and prolonged hospital stays, while IL-10 rs1800896 was linked to higher , particularly respiratory failure and sepsis. A polygenic risk score (PRS) revealed that high-risk patients had significantly elevated and . These results highlight the potential of gene polymorphisms as prognostic biomarkers and personalized treatment targets. Future research should validate these findings in larger, diverse cohorts and explore functional mechanisms.