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将胎脑皮质移植到新生大鼠脑内:对从移植组织到宿主的胼胝体和丘脑投射的逆行荧光分析

Transplantation of fetal cortex to the brain of newborn rats: a retrograde fluorescent analysis of callosal and thalamic projections from transplant to host.

作者信息

Castro A J, Zimmer J, Sunde N A, Bold E L

出版信息

Neurosci Lett. 1985 Oct 10;60(3):283-8. doi: 10.1016/0304-3940(85)90591-9.

DOI:10.1016/0304-3940(85)90591-9
PMID:4069437
Abstract

Fetal cerebral cortical tissue was transplanted into the cerebral hemisphere of 0-1-day-old rats. In some cases, the transplants were placed into or adjacent to cortical lesion cavities made immediately prior to transplantation. Injections at maturity of fast blue and diamidino yellow into the host contralateral cortex and ipsilateral thalamus demonstrated the presence of callosal and thalamic projections from transplant to host. Numerous single-labeled neurons were often arranged in cell bands or clusters. This apparent topography and the absence of double-labeling resembled normal labeling patterns.

摘要

将胎儿大脑皮质组织移植到0至1日龄大鼠的大脑半球。在某些情况下,移植组织被放置在移植前即刻形成的皮质损伤腔内或其附近。在成年时向宿主对侧皮质和同侧丘脑注射快蓝和双脒基黄,结果表明存在从移植组织到宿主的胼胝体和丘脑投射。大量单标记神经元常常排列成细胞带或细胞簇。这种明显的拓扑结构以及缺乏双标记的情况类似于正常的标记模式。

相似文献

1
Transplantation of fetal cortex to the brain of newborn rats: a retrograde fluorescent analysis of callosal and thalamic projections from transplant to host.将胎脑皮质移植到新生大鼠脑内:对从移植组织到宿主的胼胝体和丘脑投射的逆行荧光分析
Neurosci Lett. 1985 Oct 10;60(3):283-8. doi: 10.1016/0304-3940(85)90591-9.
2
Fetal cortical transplants in the cerebral hemisphere of newborn rats: a retrograde fluorescent analysis of connections.新生大鼠大脑半球的胎儿皮质移植:连接的逆行荧光分析
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Fetal neocortical transplants grafted to the cerebral cortex of newborn rats receive afferents from the basal forebrain, locus coeruleus and midline raphe.移植到新生大鼠大脑皮层的胎儿新皮层移植体接受来自基底前脑、蓝斑和中缝中线的传入神经。
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Connectional distinction between callosal and subcortically projecting cortical neurons is determined prior to axon extension.胼胝体和皮质下投射皮质神经元之间的连接差异在轴突延伸之前就已确定。
Dev Biol. 1993 Nov;160(1):1-14. doi: 10.1006/dbio.1993.1281.

引用本文的文献

1
Connectivity of fetal neocortical block transplants in the excitotoxically ablated cortex of adult rats.成年大鼠兴奋性毒素损伤皮质中胎儿新皮质块移植的连接性
Exp Brain Res. 1993;96(3):480-6. doi: 10.1007/BF00234115.
2
Neonatal hippocampal neurons, retrogradely labeled with granular blue, survive intracerebral grafting and explantation to tissue culture.用颗粒蓝逆行标记的新生海马神经元,在脑内移植和植入组织培养后仍能存活。
Exp Brain Res. 1986;65(1):213-8. doi: 10.1007/BF00243844.
3
Fetal cortical transplants in the cerebral hemisphere of newborn rats: a retrograde fluorescent analysis of connections.
新生大鼠大脑半球的胎儿皮质移植:连接的逆行荧光分析
Exp Brain Res. 1987;66(3):533-42. doi: 10.1007/BF00270686.
4
Involvement of transplanted neurons of rat embryonic neocortex in host's neocortical sensory functions.
Neurosci Behav Physiol. 1987 Sep-Oct;17(5):427-34. doi: 10.1007/BF01188733.
5
Fetal neocortical transplants grafted to the cerebral cortex of newborn rats receive afferents from the basal forebrain, locus coeruleus and midline raphe.移植到新生大鼠大脑皮层的胎儿新皮层移植体接受来自基底前脑、蓝斑和中缝中线的传入神经。
Exp Brain Res. 1988;69(3):613-22. doi: 10.1007/BF00247313.
6
Local connections in transplanted and normal cerebral cortex of rats.
Exp Brain Res. 1988;69(2):387-98. doi: 10.1007/BF00247584.
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Hippocampal neurons grafted to newborn rats establish efferent commissural connections.移植到新生大鼠体内的海马神经元建立了传出连合连接。
Exp Brain Res. 1988;72(3):577-83. doi: 10.1007/BF00250602.
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The recovery of locomotion following partial extirpation of the motor cortex and transplantation of cortical tissue in the white rat.
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