Widodo Wahyu, Aprilya Dina, Satria Oryza
Hand and Microsurgery Division, Orthopedic and Traumatology Department, Fatmawati General Hospital, Jakarta, Indonesia.
Orthop Rev (Pavia). 2025 Mar 31;17:133572. doi: 10.52965/001c.133572. eCollection 2025.
A peripheral nerve injury is a great burden for the patient and a challenge for the clinician. In a complete injury (axonotmesis or neurotmesis), the slow nature of nerve regeneration after repair or reconstruction hardly catches up to the target organ's degeneration rate, leading to a poor prognosis. The current advance in regenerative medicine has shown the potency of stem cells and their products for healing many human body structures, including the nerve. A comprehensive literature search was conducted using an internet-based search engine for current advances in regenerative medicine to augment peripheral nerve repair or reconstruction. Stem cells can differentiate into nerve cells and have paracrine and immunomodulatory effects. Its products, such as the secretome and exosome, have also been studied, and they have many benefits for the regeneration process. This novel treatment possesses significant potential to accelerate nerve healing after nerve reconstruction and potentially postpone the degenerative process in the target organ, allowing it to respond to the new signal once nerve regeneration is complete. The aim of this article is to summarized the application of stem cells and its products for nerve healing.
周围神经损伤对患者来说是巨大的负担，对临床医生而言也是一项挑战。在完全损伤（轴突断裂或神经断裂）中，修复或重建后神经再生的缓慢特性几乎无法赶上靶器官的退化速度，导致预后不良。再生医学的当前进展已显示出干细胞及其产物在治愈包括神经在内的许多人体结构方面的潜力。使用基于互联网的搜索引擎对再生医学的当前进展进行了全面的文献检索，以增强周围神经修复或重建。干细胞可以分化为神经细胞，并具有旁分泌和免疫调节作用。其产物，如分泌组和外泌体，也已得到研究，它们对再生过程有许多益处。这种新型治疗方法具有加速神经重建后神经愈合的巨大潜力，并有可能推迟靶器官的退化过程，使它在神经再生完成后能够对新信号做出反应。本文的目的是总结干细胞及其产物在神经愈合中的应用。
