Wang Yu-Dan, Liang Jian-Hong, Gao Xie-Nan, Ma Li-Li, Huang Shen-Shen, Zhang Yong-Mei
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Department of Infection Control, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Front Cell Infect Microbiol. 2025 Jul 8;15:1581545. doi: 10.3389/fcimb.2025.1581545. eCollection 2025.
To explore the role of free provision of disinfectant wipes combined with bundle management in preventing Multi-Drug Resistant Organism (MDRO) infections in the Respiratory and Intensive Care Unit (RICU).
This study included patients admitted to the RICU between January 2022 and June 2023 (control group) and from July 2023 to June 2024 (intervention group), all of whom met the inclusion criteria. The control group received standard bundle management measures, while the intervention group received unlimited use of disinfectant wipes combined with bundle management. The MDRO discovery rates and hospital-acquired infection incidence rates were compared between the two groups to assess the impact of free disinfectant wipe provision on MDRO infection prevention in the RICU.
There were no significant differences between the two groups in terms of patient age and baseline characteristics, except for Sex and the proportion of patients with chronic respiratory diseases. Notably, the MDRO discovery rate, MDRO infection rate, and hospital-acquired infection incidence were all significantly lower in the intervention group compared to the control group (MDRO discovery rate: 35.2% vs 45.9%, P<0.001; MDRO infection rate: 0.8% vs 3.5%, = 0.003; hospital-acquired infection rate: 1.5% vs 3.52%, P=0.030). However, the intervention group had more percentage of patients receiving mechanical ventilation and longer ICU stay (P < 0.05). Furthermore, in-hospital mortality was lower in the intervention group (19.5% vs 13.5%, < 0.05).
The combined intervention of unlimited use of disinfectant wipes with bundle management significantly reduced MDRO hospital-acquired infection rates and in-hospital mortality in the RICU, demonstrating its effectiveness in infection prevention.
探讨免费提供消毒湿巾联合集束化管理在预防呼吸与重症监护病房（RICU）多重耐药菌（MDRO）感染中的作用。
本研究纳入2022年1月至2023年6月入住RICU的患者（对照组）以及2023年7月至2024年6月入住的患者（干预组），所有患者均符合纳入标准。对照组接受标准集束化管理措施，而干预组接受不限量使用消毒湿巾联合集束化管理。比较两组的MDRO发现率和医院获得性感染发生率，以评估免费提供消毒湿巾对RICU中MDRO感染预防的影响。
除性别和慢性呼吸道疾病患者比例外，两组患者的年龄和基线特征无显著差异。值得注意的是，干预组的MDRO发现率、MDRO感染率和医院获得性感染发生率均显著低于对照组（MDRO发现率：35.2%对45.9%，P<0.001；MDRO感染率：0.8%对3.5%，P = 0.003；医院获得性感染率：1.5%对3.52%，P = 0.030）。然而，干预组接受机械通气的患者比例更高，ICU住院时间更长（P < 0.05）。此外，干预组的院内死亡率更低（19.5%对13.5%，P < 0.05）。
不限量使用消毒湿巾联合集束化管理的联合干预显著降低了RICU中MDRO医院获得性感染率和院内死亡率，证明了其在感染预防方面的有效性。
