Mehta Asmita A, Praveen Valiyaparambil Pavithran, Lakshmi Priya Valathara Pradeep, Anil Liya, Nair Vishnu
Department of Respiratory Medicine Amrita Institute of Medical Sciences and Research Kochi India.
Department of Endocrinology and Diabetes Amrita Institute of Medical Sciences and Research Kochi India.
Respirol Case Rep. 2025 Jul 21;13(7):e70275. doi: 10.1002/rcr2.70275. eCollection 2025 Jul.
Solitary fibrous tumours (SFTs) are rare spindle cell neoplasms, predominantly benign, comprising less than 2% of all soft tissue masses. In rare cases, SFTs can lead to Doege-Potter syndrome, a paraneoplastic condition characterised by hypoglycaemia due to elevated levels of insulin-like growth factor II (IGF-II). Patients typically present with symptomatic hypoglycaemia related to this hormonal dysregulation. We report the case of a 70-year-old man who presented with weight loss, cough, fatigue, tingling, and episodes of confusion associated with recurrent hypoglycaemia. Chest radiography revealed a large soft tissue mass in the right lower hemithorax, and CT-guided biopsy confirmed tumour infiltration in the basal segment of the right lower lobe.
孤立性纤维性肿瘤（SFTs）是罕见的梭形细胞肿瘤，多为良性，占所有软组织肿块的比例不到2%。在罕见情况下，SFTs可导致Doege-Potter综合征，这是一种副肿瘤性疾病，其特征是由于胰岛素样生长因子II（IGF-II）水平升高导致低血糖。患者通常表现为与这种激素失调相关的症状性低血糖。我们报告一例70岁男性患者，其表现为体重减轻、咳嗽、疲劳、刺痛以及与反复低血糖相关的意识模糊发作。胸部X线检查显示右下胸部有一个大的软组织肿块，CT引导下活检证实肿瘤浸润至右下叶基底段。
