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一名年轻免疫功能正常患者原发性腮腺结核与结膜结核的罕见关联:病例报告

Unusual association of primary parotid and conjunctival tuberculosis in a young immunocompetent patient: a case report.

作者信息

Hachimi Idrissi Mariam, Zaza Qamar, Benbachir Adam, Skalante Oumaima, Benaazza Soufiane, Allaoui Mohamed, Ben Lahlou Yassine, Benaissa Elmostafa, Chadli Mariama

机构信息

Department of Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco.

Department of Maxillofacial Surgery, Mohammed V Military Teaching Hospital, Rabat, Morocco.

出版信息

Access Microbiol. 2025 Jul 10;7(7). doi: 10.1099/acmi.0.000982.v3. eCollection 2025.

DOI:10.1099/acmi.0.000982.v3
PMID:40697977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12282047/
Abstract

Extrapulmonary tuberculosis often presents as lymphadenitis. In the head and neck area, tuberculous involvement of the parotid gland is rare and challenging to diagnose due to non-specific symptoms, which can be confused with a tumour. Tuberculous conjunctivitis, although uncommon, should be considered in cases of chronic, treatment-resistant conjunctivitis. The association of primary parotid and conjunctival tuberculosis is exceptional. They are difficult to diagnose due to the non-specificity of their clinical, biological and radiological signs. We report the case of a 24-year-old immunocompetent patient with no history of tuberculosis, who presented with intermittent swelling of the left parotid gland, accompanied by unilateral redness of the eye, which appeared 2 months later, in a context of fever and night sweats. The patient also reported a foreign body sensation in his eye, mild tearing and photophobia. Clinical examination revealed painful, warm swelling of the left parotid gland, as well as localized granulomatous conjunctivitis. Cervico-parotid CT and MRI revealed two well-limited, oval, left parotid formations with a slightly thickened and enhanced wall after injection of gadolinium, suggestive of abscessed collections. The diagnosis of primary parotid and conjunctival tuberculosis was made on the basis of histological examination of the biopsies, as well as direct examination, culture and GeneXpert. The patient progressed well on anti-bacillary treatment. Our work underlines the great importance of GeneXpert, which is a rapid and highly sensitive technique, effective in the diagnosis of extrapulmonary tuberculosis.

摘要

肺外结核常表现为淋巴结炎。在头颈部区域,腮腺结核受累罕见,且由于症状不具特异性,易与肿瘤混淆,诊断颇具挑战性。结核性结膜炎虽不常见,但在慢性、难治性结膜炎病例中应予以考虑。原发性腮腺结核与结膜结核同时出现的情况极为罕见。因其临床、生物学及放射学征象缺乏特异性,故难以诊断。我们报告一例24岁免疫功能正常、无结核病史的患者,其左侧腮腺间歇性肿胀,伴有发热和盗汗,2个月后出现单侧眼部发红。患者还自述眼部有异物感、轻度流泪及畏光。临床检查发现左侧腮腺疼痛、肿胀且发热,伴有局限性肉芽肿性结膜炎。颈部腮腺CT和MRI显示左侧腮腺有两个边界清晰的椭圆形病灶,注射钆后壁稍增厚且强化,提示为脓肿形成。基于活检的组织学检查以及直接检查、培养和GeneXpert检测,确诊为原发性腮腺结核和结膜结核。该患者接受抗结核治疗后病情进展良好。我们的工作强调了GeneXpert的重要性,它是一种快速且高度灵敏的技术,在肺外结核诊断中效果显著。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/12def7be71cf/acmi-7-00982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/03b58aafd931/acmi-7-00982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/406ea78f64fa/acmi-7-00982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/e2131ed8ff2d/acmi-7-00982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/12def7be71cf/acmi-7-00982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/03b58aafd931/acmi-7-00982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/406ea78f64fa/acmi-7-00982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/e2131ed8ff2d/acmi-7-00982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd9/12282047/12def7be71cf/acmi-7-00982-g004.jpg

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本文引用的文献

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Parotid Gland Tuberculosis: A Case Report and Literature Review.腮腺结核:一例报告及文献综述
Cureus. 2022 Aug 1;14(8):e27590. doi: 10.7759/cureus.27590. eCollection 2022 Aug.
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A Rare Case of Parotid Gland Tuberculosis.腮腺结核1例罕见病例
Case Rep Pediatr. 2021 Jan 6;2021:7484812. doi: 10.1155/2021/7484812. eCollection 2021.
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Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC.当细针穿刺抽吸活检(FNAC)显示可疑肿胀中有明显的中性粒细胞浸润时,不要忽视腮腺结核。
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GeneXpert MTB/RIF for rapid diagnosis and rifampin resistance detection of endobronchial tuberculosis.GeneXpert MTB/RIF 快速诊断和利福平耐药检测在支气管内结核中的应用。
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Primary Conjunctival Tuberculosis.原发性结膜结核
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