Parker R G
Cancer. 1977 Jul;40(1 Suppl):481-3. doi: 10.1002/1097-0142(197707)40:1+<481::aid-cncr2820400712>3.0.co;2-5.
Conventional radiation therapy can eradicate cancers within tissues of their origin and regional spread with conservation of anatomic structure, thus preserving function and cosmesis. New treatment methods may improve the therapeutic ratio either by increasing the frequency of tumor control or lessening the treatment-related morbidity, or both. There are several physical and biological reasons why particle radiation therapy may increase tumor cell killing without increasing normal tissue sequelae. After preliminary basic research, clinical trials of fast neutron and proton teletherapy were started. Over 700 patients were treated with fast neutron beams in 3 U.S. research programs. These studies will be extended to include negative pi mesons and heavy particles.
传统放射治疗能够在保留解剖结构的同时根除起源组织及其区域扩散范围内的癌症，从而保留功能和美观。新的治疗方法可以通过提高肿瘤控制频率或降低治疗相关的发病率，或两者兼而有之，来提高治疗比率。粒子放射治疗可能在不增加正常组织后遗症的情况下增加肿瘤细胞杀伤，这有几个物理和生物学原因。经过初步基础研究后，开始了快中子和质子远距离治疗的临床试验。在美国的3个研究项目中，超过700名患者接受了快中子束治疗。这些研究将扩展到包括负π介子和重粒子。
