Hadaegh Parto, Abdi Amir, Hasheminia Mitra, Hadaegh Farzad, Azizi Fereidoun, Tohidi Maryam
Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Nutrition Science and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Clin Lab Anal. 2025 Aug;39(15):e70075. doi: 10.1002/jcla.70075. Epub 2025 Jul 23.
To investigate the association of serum alkaline phosphatase (ALP) with incident metabolic syndrome (MetS) and its components, as well as the influence of sex on this relationship among Iranian adults.
The multivariable Cox proportional hazards regression models were applied to assess the associations between ALP both as continuous and categorical variables with incident MetS and its components.
Among 831 subjects (467 women) with a mean age of 44.51 years, during a median follow-up of 15.6 years, 597 MetS cases (336 women) occurred. Interaction was found between ALP quartiles and sex (p-value = 0.006). Among women, increasing levels of ALP across the second to fourth quartiles were associated with hazard ratios (HRs) of 1.269, 1.491, and 2.092 for MetS, respectively (p for trend < 0.001). Among men, no association was found between ALP and incident MetS. Among women, the second and fourth quartiles of ALP were associated with incident high triglycerides (TG), with HRs of 1.793 and 1.815, respectively. Moreover, a 1-SD increase in ALP conferred a 17.9% higher risk of low high-density lipoprotein cholesterol (HDL-C). Among men, a 1-SD increase in ALP was associated with an HR of 1.222 for incident high waist circumference (WC) (All p-values < 0.05).
Sex significantly influenced the impact of serum ALP on the incidence of MetS and its components. In women, ALP was a strong harbinger for incident MetS and its dyslipidemia components. However, among men, the increasing value of ALP was associated with incident central obesity but not MetS.
探讨血清碱性磷酸酶（ALP）与伊朗成年人新发代谢综合征（MetS）及其组分之间的关联，以及性别对这种关系的影响。
应用多变量Cox比例风险回归模型评估ALP作为连续变量和分类变量时与新发MetS及其组分之间的关联。
在平均年龄为44.51岁的831名受试者（467名女性）中，中位随访15.6年期间，发生了597例MetS病例（336名女性）。发现ALP四分位数与性别之间存在交互作用（p值 = 0.006）。在女性中，从第二个四分位数到第四个四分位数，ALP水平升高分别与MetS的风险比（HRs）为1.269、1.491和2.092相关（趋势p < 0.001）。在男性中，未发现ALP与新发MetS之间存在关联。在女性中，ALP的第二个和第四个四分位数与新发高甘油三酯（TG）相关，HRs分别为1.793和1.815。此外，ALP每增加1个标准差，低高密度脂蛋白胆固醇（HDL-C）风险升高17.9%。在男性中，ALP每增加1个标准差与新发高腰围（WC）的HR为1.222相关（所有p值 < 0.05）。
性别显著影响血清ALP对MetS及其组分发病率的影响。在女性中，ALP是新发MetS及其血脂异常组分的有力预兆。然而，在男性中，ALP升高与新发中心性肥胖相关，但与MetS无关。
