Nguyen Linda, Silva Andrew E, Poppe Tanya, Leung Myra, Alsweiler Jane M, Black Joanna, Harding Jane E, Tottman Anna C, Thompson Benjamin
School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada.
School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.
Hum Brain Mapp. 2025 Aug 1;46(11):e70298. doi: 10.1002/hbm.70298.
The dorsal stream vulnerability hypothesis suggests that preterm birth may preferentially impair development of the dorsal visual pathway. We explored the effects of early nutrition on dorsal stream development in a well-characterized cohort of 7-year-old children born very preterm. The children had been admitted to a tertiary hospital neonatal intensive care unit either before (OldPro group) or after (NewPro group) a parenteral nutrition protocol change that was intended to increase protein intake and reduce fluid volume intake. We assessed dorsal stream function using the blood oxygen level-dependent (BOLD) response in V1 and V5 to coherent and incoherent random dot kinematograms (RDKs), quantified using functional magnetic resonance imaging. V1 and V5 regions of interest could be localized in 24 children (OldPro n = 11, NewPro n = 13). Motion coherence thresholds, a psychophysical measure of global motion perception, were also available for 22 of these children (OldPro n = 9, NewPro n = 13). The NewPro group demonstrated a higher V5 BOLD response to RDK stimuli (OldPro: mean = 0.5%, SD = 0.2%; NewPro: mean = 1.0%, SD = 0.6%) and exhibited lower (better) motion coherence thresholds (OldPro: median = 74.0%, IQR: 59.5%-81.2%; NewPro: median = 36.8%, IQR: 27.5%-44.5%), compared to the OldPro group. The V1 BOLD response did not differ between the groups. There was a significant association between V5 ΔBOLD (coherent minus incoherent stimulus BOLD response) and motion coherence threshold. Together, these findings suggest that early nutrition may influence dorsal stream development in children born very preterm.
背侧流易损性假说表明，早产可能会优先损害背侧视觉通路的发育。我们在一组特征明确的7岁极早产儿队列中，探究了早期营养对背侧流发育的影响。这些儿童曾入住一家三级医院的新生儿重症监护病房，入住时间在旨在增加蛋白质摄入量并减少液体摄入量的肠外营养方案变更之前（旧方案组）或之后（新方案组）。我们使用功能磁共振成像对V1和V5区域对相干和不相干随机点运动图（RDKs）的血氧水平依赖（BOLD）反应来评估背侧流功能。在24名儿童中可以定位出感兴趣的V1和V5区域（旧方案组n = 11，新方案组n = 13）。其中22名儿童（旧方案组n = 9，新方案组n = 13）也有运动连贯性阈值这一全局运动感知的心理物理学测量数据。与旧方案组相比，新方案组对RDK刺激表现出更高的V5 BOLD反应（旧方案组：平均值 = 0.5%，标准差 = 0.2%；新方案组：平均值 = 1.0%，标准差 = 0.6%），并且运动连贯性阈值更低（更好）（旧方案组：中位数 = 74.0%，四分位数间距：59.5% - 81.2%；新方案组：中位数 = 36.8%，四分位数间距：27.5% - 44.5%）。两组之间的V1 BOLD反应没有差异。V5区域的BOLD反应差值（相干刺激减去不相干刺激的BOLD反应）与运动连贯性阈值之间存在显著关联。总之，这些发现表明早期营养可能会影响极早产儿的背侧流发育。
