Wu Shushan, Feng Yan, Cheng Huimin, Huang Hui, Li Yang, Ling Feng, Ma Ping, Zhong Wenxuan, Shen Ye
Department of Statistics, University of Georgia, Athens, GA, USA.
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Epidemiol Infect. 2025 Jul 24;153:e90. doi: 10.1017/S0950268825100319.
Contact tracing is an effective public health policy to put the fast-spreading epidemic under control. The government tracks the contacts of confirmed SARS-CoV-2 cases, recommends testing, encourages self-quarantine, and monitors symptoms of contacts. In developing and less-developed countries with limited resources for widespread SARS-CoV-2 testing, it remains essential to identify and quarantine positive contacts to control outbreaks. Therefore, analysing recall and precision when implementing testing policies for these contacts is necessary. We analysed a contact tracing dataset from a cohort of 827 index patients infected with SARS-CoV-2 and their 14814 close contacts from Jan 2020 to July 2020 in a province in eastern China. We constructed a network from the data and used a Graph Convolutional Network to predict each contact's infection status. To the best of our knowledge, this is the first method to use population-based contact tracing data for predicting the infection status using graph neural networks. Despite limited information, our model achieves competitive Area Under the Receiver Operating Characteristic Curve (ROC AUC) compared to hospital-onset scenarios. Based on the risk scores, we propose several contact testing policy adaptations that balance resource efficiency and effective pandemic control.
接触者追踪是一项有效的公共卫生政策,可控制快速传播的疫情。政府追踪确诊的新冠病毒病例的接触者,建议进行检测,鼓励自我隔离,并监测接触者的症状。在资源有限、无法广泛开展新冠病毒检测的发展中国家和欠发达国家,识别并隔离阳性接触者对于控制疫情爆发仍然至关重要。因此,在为这些接触者实施检测政策时分析召回率和精确度很有必要。我们分析了2020年1月至2020年7月在中国东部某省的一个队列中827名感染新冠病毒的索引患者及其14814名密切接触者的接触者追踪数据集。我们根据这些数据构建了一个网络,并使用图卷积网络预测每个接触者的感染状态。据我们所知,这是第一种使用基于人群的接触者追踪数据通过图神经网络预测感染状态的方法。尽管信息有限,但与医院发病情况相比,我们的模型在受试者操作特征曲线下面积(ROC AUC)方面具有竞争力。基于风险评分,我们提出了几种接触者检测政策调整方案,以平衡资源效率和有效的疫情控制。