Qian Hongjing, Zhang Wanli, Zhang Mingzhu, Ma Sijia, Zhen Manhong, He Hongbing, Ren Xiaobin
Yunnan Key Laboratory of Stomatology, School of Stomatology, Kunming Medical University, Kunming, China.
Department of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming Medical University, Kunming, China.
Front Pharmacol. 2025 Jul 9;16:1589035. doi: 10.3389/fphar.2025.1589035. eCollection 2025.
Yunnan Baiyao (YNBY) is a traditional Chinese medicine widely used in hemostasis, anti-inflammation, antibacterial, analgesia and wound healing. This article reviews the research progress on the pharmacological mechanism, clinical application and safety of YNBY in the past two decades. Through systematic analysis of clinical trials, animal experiments and mechanistic studies, YNBY has shown significant effects in reducing surgical bleeding (such as reducing blood loss in orthognathic surgery by 21.4%), accelerating wound healing (such as increasing the healing rate of diabetic ulcers by 37%), regulating inflammation (such as inhibiting the expression of IL-6/CRP in arthritis), and inhibiting bacterial virulence (such as destroying biofilm). Mechanistic studies have shown that YNBY acts through multiple pathways, including platelet activation, arachidonic acid metabolism regulation and autophagy regulation. However, existing studies have limitations such as inconsistent trial design and insufficient long-term safety data. This study provides a theoretical basis for optimizing the clinical application of YNBY, and points out future research directions, including the identification of active ingredients, the development of targeted delivery systems, and the development of large-scale randomized controlled trials.
云南白药是一种广泛用于止血、抗炎、抗菌、镇痛及伤口愈合的传统中药。本文综述了云南白药在过去二十年里的药理机制、临床应用及安全性方面的研究进展。通过对临床试验、动物实验及机制研究的系统分析，云南白药在减少手术出血（如正颌手术中失血减少21.4%）、加速伤口愈合（如糖尿病溃疡愈合率提高37%）、调节炎症（如抑制关节炎中IL-6/CRP的表达）及抑制细菌毒力（如破坏生物膜）方面显示出显著效果。机制研究表明，云南白药通过多种途径发挥作用，包括血小板激活、花生四烯酸代谢调节及自噬调节。然而，现有研究存在试验设计不一致及长期安全性数据不足等局限性。本研究为优化云南白药的临床应用提供了理论依据，并指出了未来的研究方向，包括活性成分的鉴定、靶向给药系统的开发以及大规模随机对照试验的开展。
