Lau A H, Chow-Tung E, Assadi F K, Fornell L, John E
Pharmacology. 1985;31(5):284-8. doi: 10.1159/000138133.
To determine the effect of dialysate osmolarity on peritoneal dialysis drug transfer, peritoneal dialysis clearances of theophylline, phenobarbital, and tobramycin were determined in 10 rabbits using dialysate containing 1.5 and 4.25% glucose. Urea and creatinine clearances were also obtained for comparison. Under similar dialysis conditions, the peritoneal clearances of the three drugs remained unchanged for the two types of dialysate. In contrast, the peritoneal clearances of urea and creatinine were significantly higher with the use of 4.25% glucose dialysate (p less than 0.001). Thus, peritoneal dialysis clearances of theophylline, phenobarbital and tobramycin are not significantly affected by hypertonicity-induced ultrafiltration during acute peritoneal dialysis.
为确定透析液渗透压对腹膜透析药物转运的影响，在10只兔中使用含1.5%和4.25%葡萄糖的透析液测定了茶碱、苯巴比妥和妥布霉素的腹膜透析清除率。同时还测定了尿素和肌酐清除率以作比较。在相似的透析条件下，两种类型透析液对三种药物的腹膜清除率无变化。相比之下，使用4.25%葡萄糖透析液时尿素和肌酐的腹膜清除率显著更高（p<0.001）。因此，在急性腹膜透析期间，高渗诱导的超滤对茶碱、苯巴比妥和妥布霉素的腹膜透析清除率无显著影响。
