Catalán Victoria, Gómez-Ambrosi Javier, Rodríguez Amaia, Salvador Javier, Frühbeck Gema
Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra, Pamplona, Spain.
Expert Opin Pharmacother. 2009 Feb;10(2):239-54. doi: 10.1517/14656560802618811.
The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders.
To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents.
Review of scientific literature.
This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.
脂肪组织的生理学在2型糖尿病的发病机制中起主要作用。脂肪细胞衍生激素以自分泌或旁分泌方式分泌，被认为是这一过程中的相关机制。从这个意义上说，给予和调节源自脂肪组织的激素成为治疗代谢紊乱的一个有吸引力的选择。
综述目前对脂肪因子在肥胖和胰岛素抵抗发生发展中的作用及其作为治疗药物的潜在用途的认识。
对科学文献进行综述。
本综述描述了脂肪因子在产生胰岛素抵抗以及伴随内脏肥胖的慢性低度炎症状态中的作用。
