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[甲状旁腺及其解剖位置变异:术前诊断与手术规划]

[Parathyroid glands and their anatomical positional variations : Preoperative diagnostics and surgical planning].

作者信息

Lenschow Christina, Pistorius Regina, Meir Michael, Schlegel Nicolas

机构信息

Klinik und Poliklinik für Allgemein‑, Viszeral‑, Transplantations‑, Gefäß- und Kinderchirurgie, Universitätsklinik Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.

出版信息

Chirurgie (Heidelb). 2025 Jul 24. doi: 10.1007/s00104-025-02343-7.

DOI:10.1007/s00104-025-02343-7
PMID:40705067
Abstract

The identification of the parathyroid glands during neck surgery can be challenging due to their variable anatomical location. Knowledge of embryonic migration, typical positions and vascular supply is therefore essential for successful surgery of the parathyroid glands. This narrative review article, supported by a systematic literature search, addresses these aspects in detail. Anatomical orientation along the recurrent laryngeal nerve and the inferior thyroid artery as key landmarks, followed by systematic cervical exploration, improves intraoperative detection rates of parathyroid glands. The anatomical variability is higher for the inferior than for the superior parathyroid glands. In cases of primary hyperparathyroidism, preoperative localization using high-resolution ultrasound and functional imaging techniques (e.g., choline positron emission tomography/computed tomography, PET/CT) enables focused parathyroidectomy, leading to a significant reduction of operation times and complication rates.

摘要

由于甲状旁腺的解剖位置多变,在颈部手术中识别它们具有挑战性。因此,了解胚胎迁移、典型位置和血管供应对于甲状旁腺的成功手术至关重要。这篇叙述性综述文章在系统文献检索的支持下,详细阐述了这些方面。沿着喉返神经和甲状腺下动脉作为关键标志进行解剖定位,随后进行系统的颈部探查,可提高术中甲状旁腺的检出率。下甲状旁腺的解剖变异比上甲状旁腺更高。在原发性甲状旁腺功能亢进的病例中,术前使用高分辨率超声和功能成像技术(如胆碱正电子发射断层扫描/计算机断层扫描,PET/CT)进行定位可实现有针对性的甲状旁腺切除术,从而显著缩短手术时间并降低并发症发生率。

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本文引用的文献

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Contribution of 18 F-fluorocholine PET-CT to the preoperative localisation of parathyroid adenoma for the treatment of primary hyperparathyroidism.18F-氟胆碱PET-CT在原发性甲状旁腺功能亢进症治疗中对甲状旁腺腺瘤术前定位的作用。
Sci Rep. 2025 Mar 23;15(1):10018. doi: 10.1038/s41598-025-94735-2.
2
A Positive Parathyroid Washout May Obviate the Need for Nuclear Scintigraphy in Parathyroid Adenoma Localization: A Retrospective Study.甲状旁腺洗脱液阳性可能无需进行甲状旁腺腺瘤定位的核素闪烁扫描:一项回顾性研究
J Otolaryngol Head Neck Surg. 2024 Jan-Dec;53:19160216241304366. doi: 10.1177/19160216241304366.
3
[F]fluorocholine PET . [Tc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency.
氟[18F]胆碱 PET 与[99mTc]甲氧基异丁基异腈闪烁扫描术在原发性甲状旁腺功能亢进症患者甲状旁腺功能亢进灶检测和定位中的应用:结果和资源效率。
Radiol Oncol. 2024 Nov 28;58(4):486-493. doi: 10.2478/raon-2024-0058. eCollection 2024 Dec 1.
4
Imaging Recommendations for Diagnosis and Management of Primary Parathyroid Pathologies: A Comprehensive Review.原发性甲状旁腺疾病诊断与管理的影像学建议:综述
Cancers (Basel). 2024 Jul 19;16(14):2593. doi: 10.3390/cancers16142593.
5
F18-Choline PET/CT or MIBI SPECT/CT in the Surgical Management of Primary Hyperparathyroidism: A Diagnostic Randomized Clinical Trial.F18-胆碱PET/CT或MIBI SPECT/CT在原发性甲状旁腺功能亢进症手术治疗中的应用:一项诊断性随机临床试验
JAMA Otolaryngol Head Neck Surg. 2024 Aug 1;150(8):658-665. doi: 10.1001/jamaoto.2024.1421.
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I-European research, the cradle of the discovery of the antidiabetic hormone: the pioneer roles and the relevance of Oskar Minkowski and Eugène Gley.我-欧洲的研究,发现抗糖尿病激素的摇篮:奥斯卡·明科夫斯基和欧仁·格雷的先驱作用和相关性。
Acta Diabetol. 2022 Dec;59(12):1635-1651. doi: 10.1007/s00592-022-01976-y. Epub 2022 Oct 14.
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Questionable value of [Tc]-sestamibi scintigraphy in patients with pHPT and negative ultrasound.甲状旁腺功能亢进症患者伴阴性超声时[Tc]- sestamibi 闪烁显像的可疑价值。
Langenbecks Arch Surg. 2022 Dec;407(8):3661-3669. doi: 10.1007/s00423-022-02648-9. Epub 2022 Aug 9.
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