Ju Hye-Min, Ahn Yong-Woo, Ok Soo-Min, Jeong Sung-Hee, Na Hee-Sam, Chung Jin
Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Busandaehak-ro 49, Mulgeum-eup, Yangsan 50612, Republic of Korea.
Department of Oral Medicine, Dental Research Institute, School of Dentistry, Pusan National University, Busandaehak-ro 49, Mulgeum-eup, Yangsan 50612, Republic of Korea.
Diagnostics (Basel). 2024 Apr 17;14(8):828. doi: 10.3390/diagnostics14080828.
Recent studies have begun exploring the potential involvement of microbiota in the pathogenesis of oral lichen planus (OLP), yet comprehensive investigations remain limited. Hence, this study aimed to compare the microbial profiles in saliva samples obtained from patients with OLP against those from healthy controls (HC), along with a comparison between erosive (E) and non-erosive (NE) OLP patients. Saliva samples were collected from 60 OLP patients (E: = 25, NE: = 35) and 30 HC individuals. Analysis revealed no significant differences in alpha diversity, as assessed by the Chao1 and Shannon index, across the three groups. However, Bray-Curtis distance analysis indicated a significant disparity in microbiome composition distribution between HC and E-OLP, as well as HC and NE-OLP groups. The six most abundant phyla observed across the groups were Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Fusobacteria, and Saccharibacteria (TM7). Notably, OLP groups exhibited a higher prevalence of Bacteroidetes. emerged as the predominant genus in the OLP groups, while showed a relatively higher prevalence in E-OLP compared to NE-OLP. This study's findings indicate a notable difference in microbiota composition between HC and patients with OLP. Additionally, differences in the microbiome were identified between the E-OLP and NE-OLP groups. The increase in the proportion of certain bacterial species in the oral microbiome suggests that they may exacerbate the inflammatory response and act as antigens for OLP.
最近的研究已开始探索微生物群在口腔扁平苔藓（OLP）发病机制中的潜在作用，但全面的调查仍然有限。因此，本研究旨在比较OLP患者与健康对照（HC）唾液样本中的微生物谱，并比较糜烂性（E）和非糜烂性（NE）OLP患者之间的微生物谱。从60例OLP患者（E组：25例，NE组：35例）和30例HC个体中收集唾液样本。分析显示，通过Chao1和香农指数评估，三组之间的α多样性没有显著差异。然而，Bray-Curtis距离分析表明，HC与E-OLP组以及HC与NE-OLP组之间的微生物群落组成分布存在显著差异。在所有组中观察到的六个最丰富的门是厚壁菌门、拟杆菌门、变形菌门、放线菌门、梭杆菌门和糖菌门（TM7）。值得注意的是，OLP组中拟杆菌门的患病率较高。 在OLP组中成为优势属，而 在E-OLP组中的患病率相对于NE-OLP组较高。本研究结果表明，HC与OLP患者之间的微生物群组成存在显著差异。此外，在E-OLP和NE-OLP组之间也发现了微生物群落的差异。口腔微生物群中某些细菌种类比例的增加表明，它们可能会加剧炎症反应，并作为OLP的抗原。
