饮酒习惯对代谢综合征伴血尿酸升高患者早期动脉粥样硬化的影响。

Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid.

机构信息

State Research Institute Centre for Innovative Medicine, 08406 Vilnius, Lithuania.

Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.

出版信息

Nutrients. 2023 Jul 27;15(15):3346. doi: 10.3390/nu15153346.

DOI:10.3390/nu15153346

PMID:37571284

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10421141/

Abstract

BACKGROUND

Hyperuricemia is perceived as one of the risk factors for developing and progressing cardiovascular disease and metabolic syndrome through various pathological mechanisms. Endogenous synthesis and exogenous factors such as diet and beverages consumed play a major role in determining serum uric acid (sUA) levels. The aim of this study was to evaluate the effect of alcohol consumption on early arterial aging in middle-aged patients with metabolic syndrome (MetS) and hyperuricemia.

MATERIALS AND METHODS

This study included 661 middle-aged subjects (241 men and 420 women) from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. Characteristics of subjects such as blood pressure, laboratory testing, and the specialized nutrition profile questionnaire were evaluated. As an early marker of arterial stiffness, carotid-femoral pulse wave velocity (cfPWV) was assessed using a non-invasive applanation tonometry technique.

RESULTS

Hyperuricemia was present in 29% of men and 34% of women. Hyperuricemic men reported 1.6 times higher rates of alcohol drinking compared to men with normal sUA levels. After analyzing the correlation between alcohol consumption and cfPWV, no statistically significant relationships were found at a significance level of α = 0.05 but lowering the significance level to 0.06 revealed significant associations in men with normal sUA (εordinal = 0.05, = 0.06) and in women with increased sUA levels (εordinal = 0.05, = 0.08). Regression analysis showed that hyperuricemic men, consuming more than one unit of alcohol per week, had a significant impact on increasing cfPWV, while men with normal sUA levels, abstaining from alcohol entirely, resulted in a statistically significant decrease in cfPWV. Our results showed statistically significant relationships only among a group of men, although the women in the hyperuricemic group had a statistically higher cfPWV than women with normal sUA levels.

CONCLUSIONS

Drinking alcohol is associated with increased arterial stiffness among hyperuricemic middle-aged men with MetS.

摘要

背景

高尿酸血症被认为是通过各种病理机制导致心血管疾病和代谢综合征发展和进展的危险因素之一。内源性合成和饮食等外源性因素以及所摄入的饮料在决定血清尿酸（sUA）水平方面起着重要作用。本研究旨在评估饮酒对患有代谢综合征（MetS）和高尿酸血症的中年患者早期动脉老化的影响。

材料和方法

本研究纳入了立陶宛高心血管风险（LitHiR）初级预防计划中的 661 名中年受试者（241 名男性和 420 名女性）。评估了受试者的血压、实验室检查和专门的营养状况问卷等特征。使用非侵入性平板张力技术评估颈动脉-股动脉脉搏波速度（cfPWV）作为动脉僵硬度的早期标志物。

结果

男性中有 29%，女性中有 34%存在高尿酸血症。高尿酸血症男性饮酒率比 sUA 水平正常的男性高 1.6 倍。在分析饮酒与 cfPWV 之间的相关性后，在显著性水平为α=0.05 时未发现具有统计学意义的关系，但将显著性水平降低至 0.06 时，在 sUA 水平正常的男性（εordinal=0.05，=0.06）和 sUA 水平升高的女性（εordinal=0.05，=0.08）中发现了具有统计学意义的关联。回归分析显示，每周饮酒超过 1 个单位的高尿酸血症男性会显著增加 cfPWV，而完全不饮酒的 sUA 水平正常的男性会使 cfPWV 显著降低。我们的结果仅显示在一组男性中具有统计学意义的关系，尽管高尿酸血症组的女性 cfPWV 高于 sUA 水平正常的女性。