Liu Renjiao, Li Zhouhuiling, Zhang Yanju, Du Meiyang, Wang Xincheng, Zhang Shi, Li Chunjun
Graduate School, Tianjin Medical University, Tianjin, People's Republic of China.
Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Oct 16;17:3783-3793. doi: 10.2147/DMSO.S481233. eCollection 2024.
Insulin resistance (IR) is a key feature of type 2 diabetes (T2D) and an independent risk factor for metabolic syndrome. Previous studies have linked elevated serum uric acid (SUA) to an increased risk of T2D.
The purpose of this study was to investigate the relationship between SUA and IR. At the same time, the correlation between New model and SUA compared with other IR alternatives was compared, so as to provide a simple and effective new indicator for early detection and prediction of IR risk and early prevention of T2D.
The first cohort was the Discovery Cohort, which included 318 obese patients. And the second cohort was the Verification Cohort, which included a total of 4333 subjects who underwent a routine health checkup at our hospital. Spearman correlation analysis and binary logistic regression analysis were used to discuss the correlation between SUA and IR.
Regardless of sex, fasting insulin (FINS) and IR replacement markers increased with SUA (P<0.001). In both cohorts, SUA was associated with IR alternatives, especially with New model, and differed between men and women in all correlation analyses. After adjusting for confounding factors, SUA was still associated with IR (P<0.001).
The correlation between SUA and IR was significantly stronger in women than in men. And the correlation between SUA and New model is stronger than other IR replacement models. However, the causal relationship between SUA and IR has not been clearly established.
胰岛素抵抗（IR）是2型糖尿病（T2D）的关键特征，也是代谢综合征的独立危险因素。既往研究已将血清尿酸（SUA）升高与T2D风险增加联系起来。
本研究旨在探讨SUA与IR之间的关系。同时，将新模型与SUA的相关性与其他IR替代指标进行比较，以便为IR风险的早期检测和预测以及T2D的早期预防提供一种简单有效的新指标。
第一个队列是发现队列，包括318名肥胖患者。第二个队列是验证队列，包括在我院进行常规健康检查的4333名受试者。采用Spearman相关分析和二元逻辑回归分析来探讨SUA与IR之间的相关性。
无论性别如何，空腹胰岛素（FINS）和IR替代指标均随SUA升高而增加（P<0.001）。在两个队列中，SUA均与IR替代指标相关，尤其是与新模型相关，且在所有相关性分析中男女存在差异。在调整混杂因素后，SUA仍与IR相关（P<0.001）。
SUA与IR之间的相关性在女性中显著强于男性。且SUA与新模型之间的相关性强于其他IR替代模型。然而，SUA与IR之间的因果关系尚未明确确立。
