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感染性阴茎假体的即刻挽救手术:手术技术与抗菌策略进展综述

Immediate salvage procedure for infected penile prostheses: A review of the advances in surgical technique and antimicrobial strategies.

作者信息

Mahdi Mohammed, Campos Lucas Ribeiro, Yafi Faysal A

机构信息

University of California, Irvine Department of Urology, Irvine, CA, USA.

Department of Urology, Hamad Medical Corporation, Doha, Qatar.

出版信息

Int J Impot Res. 2025 Jul 24. doi: 10.1038/s41443-025-01133-3.

Abstract

Penile prostheses (PPs) implantation represents a reliable treatment option for refractory erectile dysfunction (ED), yet post-operative infection remains a significant clinical challenge. Traditional management necessitates device explantation, resulting in a period of complete loss of erectile function and often a challenging delayed re-implantation due to resultant corporal scarring and penile shortening. Immediate salvage procedures, encompassing device removal followed by thorough antimicrobial washout and immediate re-implantation, offer substantial advantages with regard to penile length preservation, patient satisfaction, healthcare costs, and overall outcomes. Despite these benefits, immediate salvage procedures remain underutilized in clinical practice. Since the introduction of the Mulcahy's salvage protocol by Brant and his colleagues in 1996, numerous urologists have adopted the immediate salvage approach, reporting comparable or even superior infection-free success rates. Based on thirteen studies published over the past three decades, this review comprehensively examines their reported recent advancements in immediate salvage techniques, covering surgical innovations and evolving antimicrobial strategies.

摘要

阴茎假体(PPs)植入是治疗难治性勃起功能障碍(ED)的可靠选择,但术后感染仍是一项重大临床挑战。传统的处理方法需要取出装置,导致勃起功能完全丧失一段时间,而且由于海绵体瘢痕形成和阴茎缩短,往往会面临具有挑战性的延迟再植入。即时挽救手术,包括取出装置,随后进行彻底的抗菌冲洗并立即重新植入,在阴茎长度保留、患者满意度、医疗成本和总体结果方面具有显著优势。尽管有这些益处,但即时挽救手术在临床实践中的应用仍然不足。自1996年布兰特及其同事引入穆尔卡希挽救方案以来,许多泌尿科医生采用了即时挽救方法,报告的无感染成功率相当甚至更高。基于过去三十年发表的十三项研究,本综述全面审视了他们报告的即时挽救技术的最新进展,涵盖手术创新和不断发展的抗菌策略。

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