Auzépy P, Boutron H F, Richard C, Riou B
Rev Med Interne. 1985 Oct;6(4):373-9. doi: 10.1016/s0248-8663(85)80093-x.
Some biological data of 63 acute alcoholic poisoning (without drug ingestion) in adults were studied during a brief hospitalization. Mean arterial blood concentration of lactate was 2,34 mmol/l +/- 0,13, of ethanol was 53 +/- 3,68 mmol/l. No correlation was found between these two variables and we have not registered lactic acidosis. Arterial blood acid base balance was normal for 24 of 38 unconscious patients. The results of other fourteen showed moderate acidosis, either mixed or respiratory either metabolic, without hypoglycemia or ketonuria. No correlation between arterial blood ions H+ concentration (44,72 +/- 1,18 nmol/l (m +/- sem) and concomitant arterial blood ethanol concentration was found. Moreover, no correlation between 46 blood glucose concentrations (without prior glucose perfusion) and alcoholemia was found. Only two 18 hours fasting chronic alcoholics showed hypoglycemia. These results confirm that acute ethanol intoxication is a potential respiratory emergency in adults, and not a metabolic one (this last pattern being true for children). No confusion between acute intoxication and alcoholic ketoacidosis, alcohol induced fasting hypoglycemia or shoshin beriberi must be made.
在短期住院期间,对63例成人急性酒精中毒(无药物摄入)的一些生物学数据进行了研究。乳酸的平均动脉血浓度为2.34 mmol/L±0.13,乙醇的平均动脉血浓度为53±3.68 mmol/L。未发现这两个变量之间存在相关性,且未记录到乳酸酸中毒。38例昏迷患者中有24例动脉血酸碱平衡正常。其他14例的结果显示为中度酸中毒,为混合性或呼吸性或代谢性酸中毒,无低血糖或酮尿症。未发现动脉血氢离子浓度(44.72±1.18 nmol/L(平均值±标准误)与动脉血乙醇浓度之间存在相关性。此外,未发现46例血糖浓度(无预先葡萄糖输注)与酒精血症之间存在相关性。仅2例禁食18小时的慢性酒精中毒患者出现低血糖。这些结果证实,急性乙醇中毒在成人中是一种潜在的呼吸急症,而非代谢急症(后者在儿童中成立)。必须明确区分急性中毒与酒精性酮症酸中毒、酒精性空腹低血糖或干性脚气病。