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多种常用菌株中出现的假突变。

A spurious mutation in a wide variety of commonly used strains.

作者信息

Kniazeva Marina, Ruvkun Gary

机构信息

Molecular Biology , Massachusetts General Hospital, Boston, Massachusetts.

Genetics, Harvard Medical School, Boston, Massachusetts.

出版信息

MicroPubl Biol. 2025 Jul 9;2025. doi: 10.17912/micropub.biology.001684. eCollection 2025.

Abstract

We describe a mutant allele present in many commonly used strains. It is present in the strain, ancestral to thousands of transgenic strains generated by the Expression Project. This finding broadens the number of strains affected by the mutation, now impacting thousands of transgenic lines used in diverse studies. This expands on the previous identification of mutation in a wild-type male stock strain used for outcrossing in genetic studies.

摘要

我们描述了一种存在于许多常用品系中的突变等位基因。它存在于一个品系中,该品系是由表达项目产生的数千个转基因品系的祖先。这一发现扩大了受该突变影响的品系数量,现在影响到用于各种研究的数千个转基因品系。这扩展了之前在用于遗传研究杂交的野生型雄性原种品系中对该突变的鉴定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade1/12287765/5bcdd7096ded/25789430-2025-micropub.biology.001684.jpg

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