Peng Xin-Yu, Ji Wangqin, Lin Tao-Yan
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Anhui Provincial Key Laboratory of Synthetic Chemistry and Applications, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
State Key Laboratory of Green Pesticide, Guizhou University, Guiyang 550025, P. R. China.
Org Lett. 2025 Aug 22;27(33):9167-9172. doi: 10.1021/acs.orglett.5c02588. Epub 2025 Aug 8.
A photoredox and copper dual-catalyzed 1,4-arylcyanation of 1,3-enynes has been established using aryldibenzothiophenium salts (Ar-DBT) as aryl radical precursors, affording a wide array of tetra-substituted allenes with high chemo- and regioselectivity. This strategy exhibits a broad substrate scope with remarkable functional group tolerance, all under mild conditions. Notably, this process generates tetra-substituted allenes in a one-step reaction through the use of various electron-rich and electron-deficient aryldibenzothiophenium salts.
已开发出一种光氧化还原与铜双催化的1,3-烯炔1,4-芳基氰化反应，该反应使用芳基二苯并噻吩盐（Ar-DBT）作为芳基自由基前体，能够以高化学选择性和区域选择性得到多种四取代丙二烯。此策略底物范围广泛，对官能团具有出色的耐受性，且所有反应均在温和条件下进行。值得注意的是，通过使用各种富电子和缺电子的芳基二苯并噻吩盐，该过程能在一步反应中生成四取代丙二烯。
