Elsayed Mohamed Ahmed, Islam Md Sofiqul, Ali Safiya, Hussain Zainab, Rahman Muhammed Mustahsen, Mahmoud Okba
Department of Endodontics, RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras Al-Khaimah P.O. Box 12973, United Arab Emirates.
Department of Endodontics, Faculty of Dentistry, Assiut University, Assiut 71516, Egypt.
Dent J (Basel). 2025 Jul 9;13(7):307. doi: 10.3390/dj13070307.
Tooth discoloration is a common concern associated with the use of intra-canal medicaments, particularly those containing antibiotics. This study aims to evaluate the tooth discoloration potential of an experimental antibiotic paste modified with Nano Chitosan (APNC) and compare it with two antibiotic pastes and two calcium hydroxide-based pastes over different time intervals. : Fifty bovine incisors were standardized and prepared up to size 60. The teeth were randomly assigned into five groups based on the medicament applied: Metapaste, Metapex, modified Triple Antibiotic Paste (mTAP), Double Antibiotic Paste (DAP), and APNC. A digital spectrophotometer was used to measure the color parameters (L*, a*, and b*) at two zones, above and below the cemento-enamel junction (CEJ), across four-time points: before application (T0- baseline), immediately after application (T1), after two weeks (T2), and after one month (T3). The color changes (ΔE) were calculated and statistically analyzed using repeated-measure ANOVA. : Statistically significant differences in discoloration were observed between the tested medicaments after one month ( < 0.05). mTAP caused the highest ΔE values both above and below the CEJ at all time points, particularly after one month ( < 0.05). Conversely, APNC, Metapaste, and DAP demonstrated the least discoloration, with no significant differences among them. The degree of discoloration was time-dependent and more pronounced below the CEJ in all groups. : After one month, the experimental APNC paste induced tooth discoloration comparable to that of Metapaste, indicating minimal esthetic compromise. APNC may be a promising alternative to traditional antibiotic pastes with minimal discoloration effects.
牙齿变色是与根管内药物使用相关的一个常见问题，尤其是那些含有抗生素的药物。本研究旨在评估用纳米壳聚糖改性的实验性抗生素糊剂（APNC）导致牙齿变色的可能性，并在不同时间间隔内将其与两种抗生素糊剂和两种氢氧化钙糊剂进行比较。：将50颗牛切牙标准化并预备至60号尺寸。根据所应用的药物将牙齿随机分为五组：Metapaste、Metapex、改良三联抗生素糊剂（mTAP）、双联抗生素糊剂（DAP）和APNC。使用数字分光光度计在四个时间点测量牙骨质-釉质界（CEJ）上方和下方两个区域的颜色参数（L*、a和b）：应用前（T0 - 基线）、应用后即刻（T1）、两周后（T2）和一个月后（T3）。计算颜色变化（ΔE）并使用重复测量方差分析进行统计学分析。：一个月后，在测试药物之间观察到变色存在统计学显著差异（<0.05）。在所有时间点，mTAP在CEJ上方和下方均导致最高的ΔE值，尤其是在一个月后（<0.05）。相反，APNC、Metapaste和DAP表现出最少的变色，它们之间无显著差异。变色程度与时间相关，并且在所有组中在CEJ下方更明显。：一个月后，实验性APNC糊剂导致的牙齿变色与Metapaste相当，表明美学影响最小。APNC可能是传统抗生素糊剂的一种有前景的替代物，具有最小的变色效应。
