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犬齿牙髓对ProRoot MTA、Vitapex和Metapex反应的比较研究。

Comparative study of pulpal responses to ProRoot MTA, Vitapex, and Metapex in canine teeth.

作者信息

Kwon Woojin, Kim Ik-Hwan, Kang Chung-Min, Kim Byurira, Shin Yooseok, Song Je Seon

机构信息

Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea.

Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of Korea.

出版信息

J Dent Sci. 2021 Oct;16(4):1274-1280. doi: 10.1016/j.jds.2020.12.011. Epub 2021 Jan 8.

DOI:10.1016/j.jds.2020.12.011
PMID:34484596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8403786/
Abstract

BACKGROUND/PURPOSE: ProRoot MTA, Vitapex, and Metapex are widely used for pulp treatment of primary tooth. The aim of this study was to compare the pulpal responses to ProRoot MTA, Vitapex, and Metapex in a canine model of pulpotomy.

MATERIALS AND METHODS

Pulpotomy procedure was performed to 34 teeth (21 incisors and 13 premolars) and ProRoot MTA, Vitapex or Metapex was applicated to artificially exposed pulp tissues. After 13 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. All specimens were evaluated in several categorys related to calcific barrier, inflammatory responses and the area of calcific barrier formation was measured.

RESULTS

Most of the specimens in the ProRoot MTA group developed a calcific barrier at the pulp amputation site and showed a low level of inflammatory response. However, in comparison to ProRoot MTA group, a small amount of calcific barrier formed in Vitapex and Metapex groups.

CONCLUSION

This study found that Vitapex and Metapex induced similar pulpal responses but showed poor outcomes compared with using ProRoot MTA. Vitapex and Metapex are therefore not good substitutes for ProRoot MTA in direct pulp capping and pulpotomy.

摘要

背景/目的：ProRoot MTA、Vitapex和Metapex被广泛用于乳牙的牙髓治疗。本研究的目的是在犬类牙髓切断术模型中比较ProRoot MTA、Vitapex和Metapex对牙髓的反应。

材料与方法

对34颗牙齿（21颗切牙和13颗前磨牙）进行牙髓切断术，并将ProRoot MTA、Vitapex或Metapex应用于人工暴露的牙髓组织。13周后，拔除牙齿并用苏木精-伊红染色进行组织学评估。所有标本在与钙化屏障、炎症反应相关的几个类别中进行评估，并测量钙化屏障形成的面积。

结果

ProRoot MTA组的大多数标本在牙髓切断部位形成了钙化屏障，炎症反应水平较低。然而，与ProRoot MTA组相比，Vitapex组和Metapex组形成的钙化屏障较少。

结论

本研究发现，Vitapex和Metapex诱导的牙髓反应相似，但与使用ProRoot MTA相比，效果较差。因此，在直接盖髓和牙髓切断术中，Vitapex和Metapex不是ProRoot MTA的良好替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425f/8403786/15766236bfb5/gr1.jpg

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