Ouahabi Safae, Daoudi Nour Elhouda, Chebaibi Mohamed, Mssillou Ibrahim, Rahhou Ilyesse, Bnouham Mohamed, Hammouti Belkheir, Fauconnier Marie-Laure, Ayerdi Gotor Alicia, Rhazi Larbi, Ramdani Mohammed
Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, 724, Oujda 60000, Morocco.
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, BP 717, Oujda 60000, Morocco.
Mar Drugs. 2025 Jun 21;23(7):259. doi: 10.3390/md23070259.
The Moroccan coastline has been the focus of attention for researchers studying the national algal flora, with the aim of preserving these invaluable natural resources. Since the year 2000, these resources have stimulated great interest in the creation of new drugs, as well as their integration into food supplements and foods. Therefore, this study aims to explore the phytochemistry of a series of extracts derived from . To ensure better extraction of the various metabolites present, two extraction methods, namely maceration and the Soxhlet method, were employed using solvents of varying polarity (hexane, ethyl acetate, methanol, and water). The chemical composition of the extracts was analyzed using GC-MS for fatty acids and HPLC-DAD for phenolic compounds. Antioxidant activity was evaluated using DPPH and β-carotene bleaching assays, while antidiabetic potential was assessed by in vitro inhibition of α-amylase and α-glucosidase. In addition, Molecular docking models were employed to assess the interaction between the bioactive molecules and the human pancreatic α-amylase and α-glucosidase enzymes. Vanillin, p-coumaric acid, sinapic acid, 7,3',4'-flavon-3-ol, and kaempferol were the most abundant phenolic compounds. Anti-diabetic and antioxidant effects were highly significant.
摩洛哥海岸线一直是研究该国藻类植物群的研究人员关注的焦点，目的是保护这些宝贵的自然资源。自2000年以来，这些资源激发了人们对开发新药以及将其融入食品补充剂和食品的浓厚兴趣。因此，本研究旨在探索一系列源自……的提取物的植物化学性质。为了确保更好地提取存在的各种代谢物，采用了两种提取方法，即浸渍法和索氏提取法，使用了不同极性的溶剂（己烷、乙酸乙酯、甲醇和水）。提取物的化学成分通过气相色谱 - 质谱联用仪分析脂肪酸，通过高效液相色谱 - 二极管阵列检测器分析酚类化合物。使用DPPH和β - 胡萝卜素漂白试验评估抗氧化活性，同时通过体外抑制α - 淀粉酶和α - 葡萄糖苷酶来评估抗糖尿病潜力。此外，采用分子对接模型评估生物活性分子与人类胰腺α - 淀粉酶和α - 葡萄糖苷酶之间的相互作用。香草醛、对香豆酸、芥子酸、7,3',4'-黄酮 - 3 - 醇和山奈酚是最丰富的酚类化合物。抗糖尿病和抗氧化作用非常显著。
