Heidari Razieh, Assadollahi Vahideh, Shakib Manesh Mohammad Hossein, Mirzaei Seyed Abbas, Elahian Fatemeh
Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Int J Pharm. 2024 Nov 15;665:124654. doi: 10.1016/j.ijpharm.2024.124654. Epub 2024 Sep 5.
Wound healing is a natural process that can be disrupted by disease. Nanotechnology is a promising platform for the development of new therapeutic agents to accelerate acute and chronic wound healing. Drug delivery by means of nanoparticles as well as wound dressings have emerged as suitable options to improving the healing process. The characteristics of mesoporous silica nanoparticles (MSNs) make them efficient carriers of pharmaceutical agents alone or in combination with dressings. In order to maximize the effect of a drug and minimize its adverse consequences, it may be possible to include targeted and intelligent release of the drug into the design of MSNs. Its use to facilitate closure of adjacent sides of a cut as a tissue adhesive, local wound healing, controlled drug release and induction of blood coagulation are possible applications of MSNs. This review summarizes research on MSN applications for wound healing. It includes a general overview, wound healing phases, MSN formulation, therapeutic possibilities of MSNs and MSN-based drug delivery systems for wound healing.
伤口愈合是一个自然过程，但可能会因疾病而中断。纳米技术是开发新型治疗剂以加速急性和慢性伤口愈合的一个有前景的平台。通过纳米颗粒进行药物递送以及伤口敷料已成为改善愈合过程的合适选择。介孔二氧化硅纳米颗粒（MSN）的特性使其成为单独或与敷料结合使用的有效药物载体。为了使药物的效果最大化并将其不良后果最小化，在MSN的设计中纳入药物的靶向和智能释放可能是可行的。将其用作组织粘合剂促进切口相邻边缘闭合、局部伤口愈合、控制药物释放以及诱导血液凝固是MSN可能的应用。本综述总结了MSN在伤口愈合方面应用的研究。它包括概述、伤口愈合阶段、MSN制剂、MSN的治疗可能性以及用于伤口愈合的基于MSN的药物递送系统。
