Zhao Peidong, Ren Xiangge, Zhai Wen-Sheng
Pediatric Hospital, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
BMJ Open. 2025 Jul 25;15(7):e082591. doi: 10.1136/bmjopen-2023-082591.
Abdominal pain is one of the most common symptoms in patients with IgA vasculitis (IgAV), adversely affecting both physical and mental health. Clinical studies have demonstrated that acupuncture can quickly alleviate pain and reduce the duration of abdominal pain episodes. Given its growing acceptance in clinical practice, acupuncture is increasingly being adopted for managing IgAV-related abdominal pain. The objective of this systematic review is to evaluate and synthesise evidence regarding the efficacy and safety of acupuncture for IgAV abdominal pain.
Eight databases will be systematically searched from their inception to 1 June 2025: China National Knowledge Infrastructure, Chinese Biomedical Literature Database (China Biology Medicine), VIP Database, Wanfang Database, PubMed, Embase, Cochrane Library and Web of Science. Only randomised controlled trials investigating acupuncture for IgAV abdominal pain, published in Chinese or English, will be included. Two independent researchers will perform study selection, data extraction and risk-of-bias assessment. The primary outcomes include symptom and sign scores and time to abdominal pain resolution. Secondary outcomes comprise recurrence rate, incidence of adverse events and urinalysis results. Risk of bias will be evaluated using the Cochrane Risk of Bias Tool (V.2.0). Meta-analyses will be conducted using Review Manager software (V.5.3). For continuous data, we will calculate standardised mean differences with 95% CIs. For dichotomous outcomes, relative risks and 95% CIs will be calculated. Subgroup analyses will be performed where feasible. The overall evidence quality will be graded using the Grading of Recommendations Assessment, Development, and Evaluation approach.
Ethical approval is not required for this study as it does not involve the collection of primary patient data. The results of this meta-analysis will be disseminated through peer-reviewed publications.
CRD42023483770.
腹痛是IgA血管炎（IgAV）患者最常见的症状之一，对身心健康均有不利影响。临床研究表明，针刺可迅速缓解疼痛并缩短腹痛发作持续时间。鉴于其在临床实践中越来越被认可，针刺越来越多地被用于治疗IgAV相关的腹痛。本系统评价的目的是评估和综合针刺治疗IgAV腹痛的疗效和安全性的证据。
将从各数据库建库至2025年6月1日对八个数据库进行系统检索：中国知网、中国生物医学文献数据库（CBM）、维普数据库、万方数据库、PubMed、Embase、Cochrane图书馆和Web of Science。仅纳入以中文或英文发表的、研究针刺治疗IgAV腹痛的随机对照试验。两名独立研究人员将进行研究筛选、数据提取和偏倚风险评估。主要结局包括症状和体征评分以及腹痛缓解时间。次要结局包括复发率、不良事件发生率和尿液分析结果。将使用Cochrane偏倚风险工具（V.2.0）评估偏倚风险。将使用Review Manager软件（V.5.3）进行荟萃分析。对于连续数据，我们将计算标准化均数差及95%置信区间。对于二分结局，将计算相对风险及95%置信区间。将在可行的情况下进行亚组分析。将使用推荐分级的评估、制定和评价方法对总体证据质量进行分级。
本研究无需伦理批准，因为它不涉及收集患者原始数据。本荟萃分析的结果将通过同行评审出版物进行传播。
PROSPERO注册号：CRD42023483770。
