Ates Huseyin Aytac, Okucu Emrah, Sahin Yusuf, Karsiyakali Nejdet, Karabay Emre
Department of Urology, Istanbul Training and Research Hospital, Health Sciences University, Istanbul, 34100, Türkiye.
Department of Urology, School of Medicine, Acıbadem University, İstanbul, Turkey.
BMC Urol. 2025 Jul 25;25(1):183. doi: 10.1186/s12894-025-01865-w.
The aim of this study was to evaluate the relationship between Fatty Liver Index(FLI) and Erectile Dysfunction(ED) and its severity.
A group of 230 male patients with ED complaints underwent evaluation. Comprehensive routine blood serum tests were conducted to identify potential etiological factors contributing to ED. Additionally, waist circumference(WC) measurements were obtained to facilitate the calculation of the FLI. Participants were also asked to complete the validated Turkish adaptation of the 5-item International Index of Erectile Function (IIEF-5) questionnaire to assess the severity and impact of ED.
Out of all participants, 55 were classified as non-ED, while 175 were diagnosed with ED, mostly in the mild to moderate category. According to FLI scores, 132 had hepatic steatosis(HS). Body mass index (BMI) and WC were significantly higher in the ED group. Fasting blood glucose, ALT, and triglycerides (TG) were elevated in those with ED, while AST and total testosterone levels were lower. A significant association was found between higher FLI scores and ED ( < 0.05). The FLI score was significantly higher ( < 0.05) in the severe ED group compared to the moderate, mild-moderate, and mild ED groups.
Based on the results of our study, the FLI appears to be a simple method that shows a high correlation with the severity of ED. We believe that the use of the FLI in the diagnosis and follow-up of ED is noteworthy, and further prospective studies with larger sample sizes are needed to support this conclusion.
The online version contains supplementary material available at 10.1186/s12894-025-01865-w.
本研究旨在评估脂肪肝指数（FLI）与勃起功能障碍（ED）及其严重程度之间的关系。
对一组230名有ED主诉的男性患者进行评估。进行全面的常规血清学检查以确定导致ED的潜在病因。此外，测量腰围（WC）以方便计算FLI。参与者还被要求完成经过验证的土耳其语改编版5项国际勃起功能指数（IIEF-5）问卷，以评估ED的严重程度和影响。
在所有参与者中，55人被归类为无ED，而175人被诊断为ED，大多为轻度至中度。根据FLI评分，132人有肝脂肪变性（HS）。ED组的体重指数（BMI）和WC显著更高。ED患者的空腹血糖、谷丙转氨酶（ALT）和甘油三酯（TG）升高，而谷草转氨酶（AST）和总睾酮水平较低。发现较高的FLI评分与ED之间存在显著关联（P<0.05）。与中度、轻度-中度和轻度ED组相比，重度ED组的FLI评分显著更高（P<0.05）。
基于我们的研究结果，FLI似乎是一种与ED严重程度高度相关的简单方法。我们认为在ED的诊断和随访中使用FLI值得关注，需要进一步进行更大样本量的前瞻性研究来支持这一结论。
在线版本包含可在10.1186/s12894-025-01865-w获取的补充材料。
