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促甲状腺激素释放激素对人体血浆油酸的剂量依赖性效应。

Dose-dependent effect of TRH on plasma oleic acid in man.

作者信息

Blum C, Huron R, Desager J P, Harvengt C

出版信息

Horm Metab Res. 1977 May;9(3):228-31. doi: 10.1055/s-0028-1093542.

DOI:10.1055/s-0028-1093542
PMID:407142
Abstract

Administered to normal subjects of either sex, the TRH enhances the plasma oleic acid after 60 minutes without any significantly marked modification in the blood concentration of total FFA. The oleic acid increase is significantly dependent on the amount of administered TRH (200 microgram and greater than or equal to 400 microgram). It is accompanied by 1) a more or less pronounced but acute release of TSH, and 2) a rise in circulating T3 but a submaximal value within the time-course of the experiment (1 h). This elevation is presumably due to a preferential liberation of oleic acid by the adipose tissue, through a direct action of TSH and/or under the permissive influence of the thyroid hormone, among other factors that may intervene in the process.

摘要

将促甲状腺激素释放激素(TRH)给予不同性别的正常受试者后,60分钟时血浆油酸增加,而总游离脂肪酸(FFA)的血浓度无任何显著明显变化。油酸增加显著依赖于所给予的TRH量(200微克及大于或等于400微克)。它伴随着:1)促甲状腺激素(TSH)或多或少明显但急性的释放;2)循环中三碘甲状腺原氨酸(T3)升高,但在实验过程(1小时)内未达到最大值。这种升高可能是由于脂肪组织通过TSH的直接作用和/或在甲状腺激素的允许影响下,优先释放油酸,以及其他可能参与该过程的因素所致。

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Dose-dependent effect of TRH on plasma oleic acid in man.促甲状腺激素释放激素对人体血浆油酸的剂量依赖性效应。
Horm Metab Res. 1977 May;9(3):228-31. doi: 10.1055/s-0028-1093542.
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