Popovsky M A, Moore S B
Transfusion. 1985 Nov-Dec;25(6):573-7. doi: 10.1046/j.1537-2995.1985.25686071434.x.
Transfusion-related acute lung injury (TRALI) is an infrequent but life-threatening complication of hemotherapy. The findings in 36 cases are described. The typical clinical presentation includes acute respiratory distress characterized by hypoxemia and fulminant pulmonary edema. The onset is usually within 4 hours of transfusion and is accompanied by hypotension. In most patients (81%), recovery is rapid and complete. In 89 percent of cases, granulocyte or lymphocytotoxic antibodies are found in the serum of the implicated blood product which contained plasma. HLA-specific antibodies were identified in donor serums in 65 percent of cases evaluated. The passive transfer of these antibodies may promote complement activation and subsequent pulmonary injury. TRALI is an important cause of transfusion-associated morbidity and is probably often misdiagnosed. Blood banks need to identify donors whose plasma causes these reactions in order to prevent their recurrence.
输血相关急性肺损伤（TRALI）是血液治疗中一种罕见但危及生命的并发症。本文描述了36例患者的研究结果。典型的临床表现包括以低氧血症和暴发性肺水肿为特征的急性呼吸窘迫。发病通常在输血后4小时内，伴有低血压。大多数患者（81%）恢复迅速且完全。在89%的病例中，在含有血浆的相关血液制品血清中发现粒细胞或淋巴细胞毒性抗体。在65%接受评估的病例中，供体血清中鉴定出HLA特异性抗体。这些抗体的被动转移可能促进补体激活及随后的肺损伤。TRALI是输血相关发病的一个重要原因，可能常被误诊。血库需要识别其血浆会引发这些反应的献血者，以防止其复发。
