Kojima Reiji, Shinohara Ryoji, Kushima Megumi, Yui Hideki, Otawa Sanae, Horiuchi Sayaka, Miyake Kunio, Yokomichi Hiroshi, Akiyama Yuka, Ooka Tadao, Yamagata Zentaro
Department of Health Sciences, School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Center for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Asia Pac Allergy. 2025 Jun;15(2):57-62. doi: 10.5415/apallergy.0000000000000169. Epub 2025 Jan 8.
The higher crustacean allergy prevalence in Asia than in Western regions may be due to a shrimp-mite cross-reaction. A high environmental house dust mite prevalence may lead to increased house dust mite sensitization and thereby increase the prevalence of crustacean allergy.
To determine the association between environmental house dust mite allergens and crustacean allergy in Japanese preschool children.
We used data from 4,242 mother-infant dyads who participated in the subcohort study of the Japan Environment and Children's Study, a prospective birth cohort study. A logistic regression model was used to analyze the association between house dust mite allergens in dust at 18 months and 3 years of age and crustacean allergy at the age of 4 years.
The crustacean allergy prevalence was 0.4%. Greater house dust mite exposure at 18 months of age was associated with a higher prevalence of crustacean allergy, although this association was not statistically significant. However, there was no positive association between house dust mite exposure at 3 years of age and crustacean allergy.
No association between house dust mite allergen exposure in infancy and the risk of crustacean allergy at preschool age was apparent. Follow-up studies, including investigation of tropomyosin sensitization in schoolchildren, are required.
亚洲甲壳类过敏患病率高于西方国家，可能是由于虾与螨虫的交叉反应。家庭环境中高螨虫患病率可能导致对屋尘螨致敏增加，从而增加甲壳类过敏的患病率。
确定日本学龄前儿童环境中的屋尘螨过敏原与甲壳类过敏之间的关联。
我们使用了参与日本环境与儿童研究（一项前瞻性出生队列研究）亚队列研究的4242对母婴的数据。采用逻辑回归模型分析18个月和3岁时灰尘中的屋尘螨过敏原与4岁时甲壳类过敏之间的关联。
甲壳类过敏患病率为0.4%。18个月大时接触更多屋尘螨与甲壳类过敏患病率较高有关，尽管这种关联无统计学意义。然而，3岁时接触屋尘螨与甲壳类过敏之间没有正相关。
婴儿期接触屋尘螨过敏原与学龄前甲壳类过敏风险之间没有明显关联。需要进行后续研究，包括对学童原肌球蛋白致敏情况的调查。
