Tapias Esteban, Roberts-McDonald Marielle, Dunlap Brian, Galucia Mikayla, Ali Khalid Muhammad, Mateja Heather L
General Surgery, Western Reserve Health Education, Northeast Ohio Medical University (NEOMED), Warren, USA.
General Surgery, Ross University School of Medicine, Bridgetown, BRB.
Cureus. 2025 Jun 27;17(6):e86878. doi: 10.7759/cureus.86878. eCollection 2025 Jun.
is a Gram-negative bacterium that is commonly associated with nosocomial infections in hospitals. Due to the increasing prevalence of drug resistance, the clinical management and treatment of are becoming a significant challenge. Here, we report the case of a 21-year-old male with a history of traumatic brain injury, quadriplegia, and ventilator dependence who developed recurrent infections caused by . Over a span of nine months, the patient was diagnosed with multiple episodes of ventilator-associated pneumonia (VAP) and catheter-associated urinary tract infections (UTIs) requiring intensive care hospitalizations and antimicrobial therapy. Initially, the patient was treated with cefepime and vancomycin; however, due to the rapid rise of multidrug-resistant organisms, the treatment was modified several times with aminoglycosides, meropenem, aerosolized colistin, and ceftolozane/tazobactam. The patient's case highlights the significant challenge of multidrug-resistant and underscores the rapid progression of disease secondary to the complexity of treating infections in critically ill patients.
是一种革兰氏阴性菌，通常与医院内的医院感染有关。由于耐药性的日益普遍，其临床管理和治疗正成为一项重大挑战。在此，我们报告一例21岁男性病例，该患者有创伤性脑损伤、四肢瘫痪和呼吸机依赖史，发生了由 引起的复发性感染。在九个月的时间里，该患者被诊断出多次发生呼吸机相关性肺炎（VAP）和导管相关性尿路感染（UTI），需要重症监护住院治疗和抗菌治疗。最初，该患者接受头孢吡肟和万古霉素治疗；然而，由于多重耐药菌的迅速出现，治疗方案多次调整，使用了氨基糖苷类、美罗培南、雾化多粘菌素和头孢他啶/阿维巴坦。该患者的病例凸显了多重耐药菌带来的重大挑战，并强调了由于重症患者感染治疗的复杂性导致疾病的快速进展。
