Yang Fuyu, Chen Runze, Xiong Jun, Wang Wenzhen, Yu Peng, Wang Huilin
School of Public Administration, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Engineering Research Center of Mobile Health Management System, Ministry of Education, Hangzhou, China.
PLoS One. 2025 Jul 28;20(7):e0328543. doi: 10.1371/journal.pone.0328543. eCollection 2025.
Use the Global Burden of Disease (GBD) database to obtain gout's disease burden indicators, risk factors, 1990-2021 data in Asian countries/regions and 2050 forecast data for gout prevention and control basis.
Collect gout prevalence, incidence etc. from global burden of disease data in Asia, stratified by gender and age, analyze with statistical charts. Use Joinpoint regression model for trend analysis. Predict 2050 East Asia incidence rate with Bayesian Age-Period-Cohort (BAPC) model.
1990 - 2021, Age-standardized Prevalence Rate (ASPR) and Age-standardized Incidence Rate (ASIR) rose globally, in Asia and SDI regions. East Asia's incidence rose fast. Men's ASPR is nearly three times that of women. 55-59 - year - olds have the highest incidence rate in 2021. High BMI patients are common, and low proportion of kidney dysfunction impairment. East Asia's ASIR will rise by 2050 but slower.
Gout's disease burden rose in Asia 1990-2021. Prevalence and incidence vary by country/region, especially in East Asia. Men's prevalence is higher. 55-59 - year - olds have the highest prevalence. In Asia's developed countries, prevalence and incidence are above the global average in 2021. High BMI and kidney dysfunction impairment are key risk factors. These findings necessitate preventive strategies, enhanced cooperation in prevention and control management, public awareness campaigns, and early treatment interventions.
利用全球疾病负担（GBD）数据库获取痛风的疾病负担指标、风险因素，1990 - 2021年亚洲国家/地区的数据以及2050年的预测数据，为痛风防控提供依据。
从亚洲全球疾病负担数据中收集痛风患病率、发病率等，按性别和年龄分层，用统计图进行分析。使用Joinpoint回归模型进行趋势分析。用贝叶斯年龄 - 时期 - 队列（BAPC）模型预测2050年东亚发病率。
1990 - 2021年，全球、亚洲及社会人口指数（SDI）地区的年龄标准化患病率（ASPR）和年龄标准化发病率（ASIR）均上升。东亚发病率上升迅速。男性的ASPR几乎是女性的三倍。2021年55 - 59岁人群发病率最高。高体重指数（BMI）患者常见，肾功能障碍损害比例低。到2050年东亚的ASIR将上升但速度较慢。
1990 - 2021年亚洲痛风疾病负担上升。患病率和发病率因国家/地区而异，尤其是东亚。男性患病率更高。55 - 59岁人群患病率最高。2021年亚洲发达国家的患病率和发病率高于全球平均水平。高BMI和肾功能障碍损害是关键风险因素。这些发现需要制定预防策略，加强防控管理合作，开展公众宣传活动以及进行早期治疗干预。
