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格陵兰岛的哮喘——哮喘症状评分的制定与评估

Asthma in Greenland - development and evaluation of the asthma symptom score.

作者信息

Christiansen Christiane Hempel, Pedersen Michael Lynge, Bonefeld-Jørgensen Eva Cecilie, Nielsen Maja Hykkelbjerg

机构信息

Steno Diabetes Center Greenland, Queen Ingrid's Hospital, Nuuk, Greenland.

Greenlandic Center for Health Research, Department of Health and Nature, Ilisimatusarfik/University of Greenland, Nuuk, Greenland.

出版信息

Int J Circumpolar Health. 2025 Dec;84(1):2540684. doi: 10.1080/22423982.2025.2540684. Epub 2025 Jul 28.

Abstract

This study describes the development of the Asthma Symptom Score (ASS) and evaluates its accuracy and internal consistency in Greenlandic and Danish, using clinical interviews based on Global Initiative for Asthma guidelines as the gold standard. A cross-sectional study was conducted across all regions of Greenland, targeting citizens aged 12+, using data from the electronic medical record. The ASS ( = 94) was validated against clinical interviews using a receiver operating characteristic curve, yielding an area under the curve estimate of 0.91, indicating strong agreement. The ASS demonstrated a sensitivity of 83%, a specificity of 93%, and an overall agreement of 87%. Patients scoring 0-5 points were categorised as having controlled asthma, while those scoring 6-20 points were categorised as non-controlled. Among participants completing both the ASS and the clinical interview, 57% were classified as having non-controlled asthma. The ASS demonstrated acceptable internal consistency in both Greenlandic and Danish. These findings underscore the need for improved management of asthma in Greenland. The strong correlation between the ASS and clinical interviews suggests that the ASS may be a valuable tool in clinical practice for assessing asthma control among patients with a confirmed diagnosis. However, further validation including a larger study group, and test - retest reliability is recommended.

摘要

本研究描述了哮喘症状评分(ASS)的制定过程,并以基于全球哮喘防治创议指南的临床访谈作为金标准,评估其在格陵兰语和丹麦语中的准确性及内部一致性。利用电子病历数据,在格陵兰所有地区针对12岁及以上公民开展了一项横断面研究。通过绘制受试者工作特征曲线,将94份ASS与临床访谈结果进行验证,曲线下面积估计值为0.91,表明二者具有高度一致性。ASS的灵敏度为83%,特异度为93%,总体一致性为87%。得分为0 - 5分的患者被归类为哮喘得到控制,而得分6 - 20分的患者被归类为哮喘未得到控制。在同时完成ASS和临床访谈的参与者中,57%被归类为哮喘未得到控制。ASS在格陵兰语和丹麦语中均显示出可接受的内部一致性。这些发现强调了在格陵兰改善哮喘管理的必要性。ASS与临床访谈之间的强相关性表明,ASS可能是临床实践中评估确诊患者哮喘控制情况的一种有价值的工具。然而,建议进一步开展包括更大研究组的验证以及重测信度研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab78/12305869/1353e711213d/ZICH_A_2540684_F0001_OC.jpg

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