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采用整合原子研究法评估羽扇豆蛋白水解物的肝脏脂质组学和抗炎活性。

Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.

作者信息

Casati Sara, Dei Cas Michele, d'Adduzio Lorenza, Cruz-Chamorro Ivan, Santos-Sánchez Guillermo, Bollati Carlotta, Fanzaga Melissa, Pedroche Justo, Millán-Linares María Del Carmen, Roda Gabriella, Carrillo-Vico Antonio, Lammi Carmen

机构信息

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

出版信息

NPJ Sci Food. 2025 Jul 28;9(1):154. doi: 10.1038/s41538-025-00515-7.

DOI:10.1038/s41538-025-00515-7
PMID:40721609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12304282/
Abstract

Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improving the lipidomic and anti-inflammatory profile. To achieve this objective, a lipidomic approach in combination with the evaluation of protein level modulation of selected key enzymes that are pivotal involved in the bioactive lipid pathway synthesis/regulation was performed on liver homogenates. Specifically, LPH positively impacted DHCer, SM, LacCer, Sph 1, DHSph 1, and S1P 1 concentrations, and restored the basal conditions of ASAH1 and ASM, proteins involved in sphingolipid metabolism. LPH also reduced the FASN and PPARγ levels and eicosanoids, with positive modulation of the COX-2 and ALOX5. Additionally, LPH reduced the WB-induced AEA and 2AG concentrations.

摘要

慢性炎症在代谢功能障碍相关疾病的发生和发展中起重要作用。本研究在西方饮食（WD）小鼠模型中研究羽扇豆蛋白水解物（LPH），旨在阐明其在改善脂质组学和抗炎方面的潜在有益作用。为实现这一目标，对肝脏匀浆进行了脂质组学方法，并评估了参与生物活性脂质途径合成/调节的选定关键酶的蛋白质水平调节。具体而言，LPH对二氢神经酰胺（DHCer）、鞘磷脂（SM）、乳糖神经酰胺（LacCer）、鞘氨醇1（Sph 1）、二氢鞘氨醇1（DHSph 1）和1-磷酸鞘氨醇（S1P 1）的浓度产生积极影响，并恢复了参与鞘脂代谢的蛋白质酸性神经酰胺酶1（ASAH1）和酸性鞘磷脂酶（ASM）的基础水平。LPH还降低了脂肪酸合酶（FASN）和过氧化物酶体增殖物激活受体γ（PPARγ）的水平以及类花生酸，并对环氧合酶-2（COX-2）和5-脂氧合酶（ALOX5）产生正向调节作用。此外，LPH降低了西方饮食诱导的花生四烯乙醇胺（AEA）和2-花生四烯酸甘油（2AG）的浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/0971baf21e2c/41538_2025_515_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/fe6a22ff4270/41538_2025_515_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/b4c2f11c097b/41538_2025_515_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/d2c67041f932/41538_2025_515_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/bbbfa1117576/41538_2025_515_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/0971baf21e2c/41538_2025_515_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/fe6a22ff4270/41538_2025_515_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/b4c2f11c097b/41538_2025_515_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/d2c67041f932/41538_2025_515_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/bbbfa1117576/41538_2025_515_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/12304282/0971baf21e2c/41538_2025_515_Fig5_HTML.jpg

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