Lukashevich I S, Orlova S V, Mar'iankova R F, Barkar N D
Vopr Virusol. 1985 Sep-Oct;30(5):595-9.
Pathogenicity for randombred and inbred mice of various age groups of the standard Lassa virus and the virus enriched with defective interfering particles (DIP) was studied. The standard Lassa virus inoculated intracerebrally caused 100% death of C3H/Sn mice aged up to 4 weeks and 60%-70% death of randombred white mice aged 3-4 weeks. BALB/C mice were found to be nonsusceptible to the virus, and its lethality for C57BL/6 and AKR mice varied within the range of 30%-60%. Lassa virus enriched with DIP caused no death of the susceptible animals and showed poor protective activity against the standard virus.
研究了标准拉沙病毒以及富含缺陷干扰颗粒（DIP）的病毒对不同年龄组随机繁殖和近交系小鼠的致病性。脑内接种标准拉沙病毒导致4周龄及以下的C3H/Sn小鼠100%死亡，3 - 4周龄的随机繁殖白色小鼠60% - 70%死亡。发现BALB/C小鼠对该病毒不敏感，其对C57BL/6和AKR小鼠的致死率在30% - 60%范围内变化。富含DIP的拉沙病毒未导致易感动物死亡，且对标准病毒的保护活性较差。
