Feizy Javad, Rahimi Atieh, Tabari Damoon Ghofrani, Zarghami Mohammad Reza, Jahani Moslem, Moradi Elahe
Department of Food Safety and Quality Control, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran.
Department of Research and Development, Javaneh Khorasan Company, Mashhad, Iran.
Sci Rep. 2025 Jul 28;15(1):27513. doi: 10.1038/s41598-025-13249-z.
Mycotoxins-harmful compounds produced by various fungi, particularly in agricultural products-pose serious threats to food safety and to the health of both humans and livestock. These toxins can cause liver and kidney damage and may even be carcinogenic. Therefore, it is essential to mitigate their harmful effects through practical and cost-effective methods. In this study, we investigated the effectiveness of a mycotoxin binder composed of organic and inorganic materials with varying formulations for the removal of aflatoxins, ochratoxin, zearalenone, and deoxynivalenol under simulated gastric and intestinal conditions. Among the tested formulations, the mixture containing bentonite, humic acid, and beta-glucan-mannan in a 70:10:20 ratio showed the highest overall adsorption efficiency. This optimized formulation resulted in a statistically significant improvement in toxin removal (P < 0.05), achieving removal rates of 98.07% for aflatoxin B, 93.80% for aflatoxin B, 90.99% for aflatoxin G, 93.56% for aflatoxin G, 81.64% for ochratoxin, 73.45% for zearalenone, and 98.98% for deoxynivalenol. These findings offer a promising strategy for improving agricultural product safety and enhancing food supply chain integrity.
霉菌毒素——由各种真菌产生的有害化合物，尤其是在农产品中——对食品安全以及人类和牲畜的健康构成严重威胁。这些毒素会导致肝脏和肾脏损伤，甚至可能致癌。因此，通过切实可行且经济高效的方法减轻其有害影响至关重要。在本研究中，我们研究了一种由有机和无机材料组成、配方各异的霉菌毒素吸附剂在模拟胃和肠道条件下对黄曲霉毒素、赭曲霉毒素、玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇的去除效果。在测试的配方中，膨润土、腐殖酸和β-葡聚糖-甘露聚糖以70:10:20的比例混合显示出最高的总体吸附效率。这种优化配方在毒素去除方面有统计学意义的显著改善（P < 0.05），黄曲霉毒素B1的去除率达到98.07%，黄曲霉毒素B2的去除率为93.80%，黄曲霉毒素G1的去除率为90.99%，黄曲霉毒素G2的去除率为93.56%，赭曲霉毒素的去除率为81.64%，玉米赤霉烯酮的去除率为73.45%，脱氧雪腐镰刀菌烯醇的去除率为98.98%。这些发现为提高农产品安全性和加强食品供应链完整性提供了一个有前景的策略。
