Dyeshana Hermina Manjekana, Zuma Sibusiso Memory
Department of Health Studies, University of South Africa, Pretoria, South Africa.
BMC Pregnancy Childbirth. 2025 Jul 28;25(1):792. doi: 10.1186/s12884-025-07909-1.
South Africa (SA) is amongst the countries that adopted the Global plan towards the elimination of new HIV infections amongst children and keeping their mothers alive, launched in June 2011 as well the global HIV strategies of the Sustainable Development Goal (SDG) 3.3 target of ending the HIV epidemic by 2030, including the strategy for measuring impact and progress made in the prevention of mother-to-child transmission (PMTCT), now called Vertical Transmission Prevention (VTP) of HIV and communicable infections. All targets outlined in the Global Plan for elimination of Mother to child transmission (eMTCT) have almost been reached by the country, showing potential to achieve eMTCT by 2030.Successes are attributed to PMTCT policy of SA being amongst the best in the world. However, despite the well-established PMTCT programme, PMTCT implementation gaps still exist. This study ascertained identified gaps as follows: Of 163 accounted for pregnant women participants, 82(53.0%) booked before 20 weeks of gestational dates for their first ANC booking as advocated for by the PMTCT policy,81 were late bookers who had potential for not having their viral load suppressed, with high risk of MTCT.15 were missing and unaccounted for. 91 of 101 (89.11%) pregnant HIV positive women commenced ART on the day of their diagnosis, during their first ANC attendance. 67 were known HIV positive pregnant women already on ART who came for their first booking The remaining 10 pregnant HIV positive women did not begin ART early in their pregnancy and have the potential of not being virally suppressed Viral load was poorly monitored-25.0% had no viral load testing done at their first ANC booking,47% were tested at delivery and 49.0% tested at 6-months after delivery.150 of 164 HIV positive women who were eligible for a routine six-to-twelve-week post-partum were missed opportunities.100 of 178 (56.2%) HIV exposed babies were given NVP and AZT prophylaxis Baby Polymerase Chain Reaction(PCR) testing:Of 178 HIV exposed babies, 122 (69%) were tested at birth, 113 of 178(63%) were tested at 10 weeks There was 6 (3.5%) of babies who seroconverted after 103 of 178 (58%) were tested. at 6-months.
To address identified gaps, inform future policy formulation and improve PMTCT practices, ascertaining the country to achieve eMTCT by 2030.
To conduct file audit at selected facilities to assess and verify the existence of implementation gaps.
A quantitative, cross-sectional survey of routinely collected clinic data. The survey was chosen to conduct clinical records audits of mother and baby pairs client records from 18 facilities rendering PMTCT services, representative of the rural and urban areas in all the nine provinces of SA Five (5) Mother and baby pairs client records, each containing specific tools used for measuring PMTCT programme progress amounting to 3 160 files were randomly selected. The investigator developed a checklist from all existing approved PMTCT M&E sampled tools, condensed into one document and used to collect data from all sampled client's records. STATA software was used for data analysis.
The audit revealed several factors, related to non-compliance to interventions of the PMTCT policy, poor integration of mother and baby services; poor client management and poor documentation practices.
The results indicate that, despite, the well-established PMTCT programme in place in the country, implementation gaps still exist as a result of non-compliance to the PMTCT policy. There is an urgent need to prioritise and support implementers to fully implement the PMTCT policy.
The study ascertained PMTCT policy implementation gaps that still exist as a result of non- compliance to interventions advocated for by the PMTCT policy Poor adherence and non -adherence to PMTCT policy may have an impact on the ultimate objectives of the whole program and derail the country to achieve eMTCT by 2030.
南非是采纳2011年6月发起的《全球消除儿童新发艾滋病毒感染并确保其母亲存活计划》以及可持续发展目标3.3中到2030年终结艾滋病毒流行这一全球艾滋病毒战略的国家之一,包括衡量预防母婴传播(PMTCT,现称为艾滋病毒和传染病垂直传播预防,即VTP)方面所取得影响和进展的战略。该国几乎实现了《消除母婴传播全球计划》(eMTCT)中概述的所有目标,显示出到2030年实现eMTCT的潜力。成功归因于南非的PMTCT政策是世界上最好的政策之一。然而,尽管PMTCT计划已成熟,但PMTCT的实施仍存在差距。本研究确定了以下差距:在163名有记录的孕妇参与者中,82名(占53.0%)按照PMTCT政策的倡导,在妊娠20周前进行了首次产前检查登记,81名登记较晚,有可能无法抑制其病毒载量,母婴传播风险高。15名去向不明且未登记。101名艾滋病毒呈阳性的孕妇中,91名(占89.11%)在确诊当天、首次产前检查时开始接受抗逆转录病毒治疗(ART)。67名是已知已在接受ART治疗的艾滋病毒呈阳性孕妇,她们前来进行首次登记。其余10名艾滋病毒呈阳性的孕妇在孕期未尽早开始ART治疗,有可能无法实现病毒抑制。病毒载量监测不力——25.0%的孕妇在首次产前检查登记时未进行病毒载量检测,47%在分娩时检测,49.0%在产后6个月检测。164名符合产后常规6至12周检查条件的艾滋病毒呈阳性妇女中有150名失去了检查机会。178名艾滋病毒暴露婴儿中,100名(占56.2%)接受了奈韦拉平(NVP)和齐多夫定(AZT)预防治疗。婴儿聚合酶链反应(PCR)检测:178名艾滋病毒暴露婴儿中,122名(占69%)在出生时接受检测,178名中的113名(占63%)在10周时接受检测。178名中的103名(占58%)在6个月时接受检测,其中6名(占3.5%)婴儿血清转化。
为解决已发现的差距,为未来政策制定提供信息并改进PMTCT做法,确保该国到2030年实现eMTCT。
在选定机构进行档案审计,以评估和核实实施差距的存在情况。
对常规收集的诊所数据进行定量横断面调查。该调查旨在对提供PMTCT服务的18家机构(代表南非九个省的农村和城市地区)的母婴对客户记录进行临床记录审计。从用于衡量PMTCT计划进展的所有现有批准的监测和评价抽样工具中制定了一份清单,浓缩成一份文件,并用于从所有抽样客户记录中收集数据。使用STATA软件进行数据分析。
审计发现了几个因素,与未遵守PMTCT政策干预措施、母婴服务整合不佳、客户管理不善和文件记录做法不佳有关。
结果表明,尽管该国PMTCT计划已成熟,但由于未遵守PMTCT政策,实施差距仍然存在。迫切需要优先考虑并支持实施者全面实施PMTCT政策。
该研究确定了由于未遵守PMTCT政策倡导的干预措施而仍然存在的PMTCT政策实施差距。对PMTCT政策的依从性差和不依从可能会影响整个计划的最终目标,并使该国到2030年实现eMTCT的目标脱轨。