Lv Xin, Liu Jie, Ma Shuo, Wang Yuhan, Pan Yixin, Qiu Xian, Cao Yu, Sun Bomin, Zhan Shikun
Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
J Zhejiang Univ Sci B. 2025 Jun 23;26(7):694-707. doi: 10.1631/jzus.B2400048.
Abuse of amphetamine-based stimulants is a primary public health concern. Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants. However, the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure (AME) on sleep homeostasis remain to be explored. This study employed non-human primates and electroencephalogram (EEG) sleep staging to evaluate the influence of AME on neural oscillations. The primary focus was on alterations in spindles, delta oscillations, and slow oscillations (SOs) and their interactions as conduits through which AME influences sleep stability. AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2 (NREM2) stage, and impacts SOs and delta waves differentially. Furthermore, the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine. Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability. In summary, this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.
基于苯丙胺的兴奋剂滥用是一个主要的公共卫生问题。最近的研究强调了处方类基于苯丙胺的兴奋剂不当使用情况令人不安的升级。然而，急性甲基苯丙胺暴露（AME）对睡眠稳态影响的神经生理机制仍有待探索。本研究采用非人类灵长类动物和脑电图（EEG）睡眠分期来评估AME对神经振荡的影响。主要重点在于纺锤波、δ振荡和慢振荡（SOs）的变化及其相互作用，这些是AME影响睡眠稳定性的途径。AME主要减少非快速眼动2（NREM2）阶段的睡眠纺锤波，并对SOs和δ波产生不同影响。此外，甲基苯丙胺选择性地增强了与睡眠纺锤波嵌套的SO/δ波之间的竞争关系。复杂性分析还表明，嵌套有SO的纺锤波失去了维持睡眠深度和稳定性的能力。总之，这一发现可能是AME破坏睡眠稳态的内在电生理机制之一。
