Chan Wing Yu, Hobi Stefan, Ferguson Andrew, Elsohaby Ibrahim
Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR 999077, China.
Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR 999077, China.
Antibiotics (Basel). 2025 Jul 6;14(7):685. doi: 10.3390/antibiotics14070685.
: Canine pyoderma and otitis externa are prevalent bacterial skin infections in veterinary practice, frequently complicated by the emergence of multidrug-resistant (MDR) pathogens. To investigate the frequency, antimicrobial resistance (AMR) profiles, and frequency of MDR bacterial isolates from dogs with pyoderma or otitis externa in Hong Kong. : A retrospective study of bacterial isolates from 215 clinical samples collected from dogs presenting with pyoderma ( = 63) or otitis externa ( = 152) at veterinary clinics across Hong Kong between 2018 and 2022. Bacterial isolates were identified and subjected to antimicrobial susceptibility testing against 13 antimicrobial classes. : spp., particularly , were the most commonly isolated species, followed by spp. and spp. High resistance rates were observed for orbifloxacin (61.3% in pyoderma; 76.7% in otitis externa), doxycycline (59.3%; 69.2%), clindamycin (62%; 68.9%), and enrofloxacin (50%; 55.5%). Most isolates were sensitive to ofloxacin, ticarcillin-clavulanate, tobramycin, ciprofloxacin, cefpodoxime, cefuroxime, and cefixime. MDR was detected in 67.5% of pyoderma and 66.8% of otitis externa isolates. Gram-negative bacteria exhibited significantly higher MDR rates than Gram-positive isolates. The multiple antibiotic resistance (MAR) index averaged 0.41 for pyoderma and 0.52 for otitis externa isolates. We found no significant associations between MDR and non-modifiable risk factors (i.e., age, sex, breed, and reproductive status). : These findings highlight the critical need for prudent antimicrobial use and continuous surveillance of AMR trends in companion animals. A higher focus should be placed on topical antiseptic therapy, with oral antibiotics used only in exceptional cases and after susceptibility testing. From a One Health perspective, the potential transmission of MDR bacteria between companion animals and humans underscores the importance of a coordinated approach to antimicrobial stewardship across both veterinary and human medicine.
犬脓皮病和外耳炎是兽医临床中常见的细菌性皮肤感染，常因多重耐药（MDR）病原体的出现而复杂化。为了调查香港患有脓皮病或外耳炎的犬中多重耐药细菌分离株的频率、抗菌药物耐药性（AMR）谱以及频率。：对2018年至2022年期间从香港各地兽医诊所就诊的患有脓皮病（n = 63）或外耳炎（n = 152）的犬收集的215份临床样本中的细菌分离株进行回顾性研究。对细菌分离株进行鉴定，并对13类抗菌药物进行药敏试验。：葡萄球菌属，尤其是金黄色葡萄球菌，是最常分离出的菌种，其次是链球菌属和假单胞菌属。观察到奥比沙星（脓皮病中为61.3%；外耳炎中为76.7%）、强力霉素（59.3%；69.2%）、克林霉素（62%；68.9%）和恩诺沙星（50%；55.5%）的耐药率较高。大多数分离株对氧氟沙星、替卡西林-克拉维酸、妥布霉素、环丙沙星、头孢泊肟、头孢呋辛和头孢克肟敏感。在67.5%的脓皮病分离株和66.8%的外耳炎分离株中检测到多重耐药。革兰氏阴性菌的多重耐药率显著高于革兰氏阳性分离株。脓皮病分离株的多重抗生素耐药（MAR）指数平均为0.41，外耳炎分离株为0.52。我们发现多重耐药与不可改变的风险因素（即年龄、性别、品种和生殖状态）之间没有显著关联。：这些发现凸显了谨慎使用抗菌药物以及持续监测伴侣动物抗菌药物耐药趋势的迫切需求。应更加注重局部抗菌治疗，仅在特殊情况下并在药敏试验后使用口服抗生素。从“同一健康”的角度来看，多重耐药细菌在伴侣动物和人类之间的潜在传播凸显了兽医和人类医学中协调抗菌药物管理方法的重要性。
